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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08439(IL2RG Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P08439(IL2RG Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The interleukin-2 receptor gamma chain (IL2RG), also known as CD132. is a critical component of multiple cytokine receptors, including those for IL-2. IL-4. IL-7. IL-9. IL-15. and IL-21. It functions as a common signaling subunit shared by these receptors, enabling signal transduction through JAK-STAT pathways to regulate immune cell development, proliferation, and homeostasis. Mutations in the IL2RG gene cause X-linked severe combined immunodeficiency (SCID-X1), a life-threatening disorder characterized by absent T and NK cells and dysfunctional B cells.

IL2RG antibodies are widely used to study immune system regulation, particularly in immunodeficiency research and hematopoietic cell signaling. These antibodies enable detection of IL2RG protein expression via techniques like flow cytometry, Western blotting, and immunohistochemistry. They also assist in characterizing immune cell subsets and monitoring receptor activation states. In translational research, IL2RG antibodies support the evaluation of gene therapy strategies for SCID-X1 and the development of IL2RG-targeted therapeutics. Additionally, IL2RG-deficient mice (e.g., NSG mice) are essential models for human immune system studies, where IL2RG antibodies help validate genetic modifications. Their applications extend to cancer immunotherapy research, as IL2RG signaling influences T-cell survival and antitumor responses.