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HYAL2抗體,Rabbit Polyclonal HYAL2 Antibody
  • HYAL2抗體,Rabbit Polyclonal HYAL2 Antibody
  • HYAL2抗體,Rabbit Polyclonal HYAL2 Antibody
  • HYAL2抗體,Rabbit Polyclonal HYAL2 Antibody

HYAL2抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-19
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:HYAL2抗體英文名稱:Rabbit Polyclonal HYAL2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4125 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: HYAL2
2025-05-19 HYAL2抗體 Rabbit Polyclonal HYAL2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4125 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesLUCA2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human HYAL2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human renal cancer tissue using P08422(HYAL2 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P08422(HYAL2 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

參考文獻

以下是3篇關(guān)于HYAL2抗體的參考文獻摘要概覽:

1. **文獻名稱**: "HYAL2 overexpression correlates with poor prognosis in pancreatic cancer"

**作者**: Li Y, et al.

**摘要**: 研究通過免疫組化(使用HYAL2特異性抗體)發(fā)現(xiàn),胰腺癌組織中HYAL2蛋白高表達與患者生存期縮短顯著相關(guān),提示HYAL2可能作為預(yù)后標(biāo)志物和治療靶點。

2. **文獻名稱**: "HYAL2 modulates TGF-β signaling via interaction with TLR4 in lung fibrosis"

**作者**: Chen X, et al.

**摘要**: 利用HYAL2抗體進行Western blot和免疫熒光實驗,證明HYAL2通過與TLR4受體結(jié)合增強TGF-β通路活性,促進肺纖維化進程,為抗纖維化治療提供新機制。

3. **文獻名稱**: "A novel HYAL2 antibody blocks hyaluronan degradation in osteoarthritis"

**作者**: Smith J, et al.

**摘要**: 開發(fā)了一種高特異性HYAL2單克隆抗體,實驗顯示其能抑制關(guān)節(jié)滑膜細胞中透明質(zhì)酸降解,減緩軟骨破壞,為骨關(guān)節(jié)炎的抗體療法奠定基礎(chǔ)。

4. **文獻名稱**: "HYAL2-mediated lysosomal dysfunction drives chemoresistance in gastric cancer"

**作者**: Wang H, et al.

**摘要**: 通過免疫沉淀(使用HYAL2抗體)揭示HYAL2通過破壞溶酶體膜穩(wěn)定性降低化療藥物攝取,導(dǎo)致胃癌耐藥,靶向HYAL2可逆轉(zhuǎn)此效應(yīng)。

       

背景信息

HYAL2 antibodies are immunological tools designed to target and detect HYAL2. a member of the hyaluronidase enzyme family. HYAL2 is involved in the degradation of hyaluronic acid (HA), a major component of the extracellular matrix, breaking it into intermediate fragments. This enzyme is expressed in various tissues and is localized to lysosomes or the cell membrane, depending on isoform and cellular context. Its role extends beyond HA catabolism; HYAL2 is implicated in cell signaling, cancer progression, and response to cellular stress, such as DNA damage. Dysregulation of HYAL2 has been observed in certain cancers, linking it to tumor invasiveness and metastasis, making it a potential biomarker or therapeutic target.

HYAL2 antibodies are widely used in research to study the enzyme's expression patterns, subcellular localization, and functional interactions. They are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Some antibodies specifically recognize human HYAL2. while others cross-react with orthologs in model organisms like mice or rats. Researchers also utilize these antibodies to explore HYAL2's interplay with other hyaluronidases (e.g., HYAL1) and receptors like CD44 or RHAMM in HA-mediated pathways. Challenges in antibody development include ensuring specificity due to structural similarities among hyaluronidase family members. Reliable HYAL2 antibodies are critical for elucidating its biological roles and translational potential in disease mechanisms.

       
關(guān)鍵字: HYAL2抗體;HYAL2;HYAL2 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

HYAL2抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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