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DNAJA1抗體,Rabbit Polyclonal DNAJA1 Antibody
  • DNAJA1抗體,Rabbit Polyclonal DNAJA1 Antibody
  • DNAJA1抗體,Rabbit Polyclonal DNAJA1 Antibody
  • DNAJA1抗體,Rabbit Polyclonal DNAJA1 Antibody

DNAJA1抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-19
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:DNAJA1抗體英文名稱:Rabbit Polyclonal DNAJA1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4124 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: DNAJA1
2025-05-19 DNAJA1抗體 Rabbit Polyclonal DNAJA1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4124 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesDJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSPF4; NEDD7; hDJ-2
WB Predicted band size45 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human DNAJA1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 231 cells, A431 cells, Raji cells, Jurkat cells, HepG2 cells, Primary antibody: P08421(DNAJA1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08421(DNAJA1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08421(DNAJA1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于DNAJA1抗體的3篇代表性文獻(xiàn)的簡要概括(注:以下內(nèi)容為示例,非真實文獻(xiàn)):

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1. **文獻(xiàn)名稱**:DNAJA1 overexpression promotes colorectal cancer metastasis via HSP90-mediated stabilization of β-catenin

**作者**:Li X, et al.

**摘要**:該研究利用DNAJA1抗體檢測其在結(jié)直腸癌組織中的表達(dá)水平,發(fā)現(xiàn)DNAJA1高表達(dá)與患者預(yù)后不良相關(guān)。機制研究表明,DNAJA1通過結(jié)合HSP90增強β-catenin蛋白穩(wěn)定性,激活Wnt信號通路,促進(jìn)腫瘤侵襲轉(zhuǎn)移。

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2. **文獻(xiàn)名稱**:DNAJA1 modulates α-synuclein aggregation in Parkinson’s disease models

**作者**:Smith J, et al.

**摘要**:通過免疫沉淀(使用DNAJA1抗體)和細(xì)胞模型,研究發(fā)現(xiàn)DNAJA1與α-synuclein相互作用,抑制其異常聚集。敲低DNAJA1會加劇多巴胺能神經(jīng)元死亡,提示其在帕金森病中具有神經(jīng)保護(hù)作用。

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3. **文獻(xiàn)名稱**:Prognostic significance of DNAJA1 in hepatocellular carcinoma: A tissue microarray study

**作者**:Wang Y, et al.

**摘要**:基于組織芯片和DNAJA1抗體的免疫組化分析,研究發(fā)現(xiàn)DNAJA1在肝細(xì)胞癌中高表達(dá),并與腫瘤分級、血管浸潤顯著相關(guān)。多變量分析表明,DNAJA1是獨立的預(yù)后標(biāo)志物,可能作為治療靶點。

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如需真實文獻(xiàn),建議通過PubMed或Google Scholar搜索關(guān)鍵詞“DNAJA1 antibody”、“DNAJA1 biomarker”或“DNAJA1 function”獲取最新研究。

       

背景信息

DNAJA1 antibody is a research tool targeting DNAJA1. a member of the Hsp40 (heat shock protein 40) family. Also known as Hdj2 or HdjA, DNAJA1 functions as a co-chaperone for Hsp70 proteins, assisting in protein folding, stress response, and cellular homeostasis. It contains a conserved J-domain that interacts with Hsp70 and additional domains (G/F and C-terminal regions) involved in substrate binding. DNAJA1 is implicated in various pathologies, including cancer, where it exhibits dual roles—acting as an oncogene in breast and liver cancers by promoting cell proliferation, while showing tumor-suppressive effects in colorectal cancer. It also participates in neurodegenerative diseases like Parkinson's by modulating protein aggregation.

The antibody enables detection and quantification of DNAJA1 in techniques such as Western blotting, immunoprecipitation, and immunohistochemistry. Its applications extend to studying DNAJA1's interactions with client proteins (e.g., EGFR, PTEN) and regulatory mechanisms under stress conditions. Commercial DNAJA1 antibodies are typically developed in rabbit or mouse hosts, validated for specificity across human and common model organisms. Recent studies emphasize its role in cancer metabolism, drug resistance, and viral infection pathways, making it valuable for both basic research and therapeutic target exploration. Proper validation using knockout controls remains essential due to potential cross-reactivity with other Hsp40 family members.

       
關(guān)鍵字: DNAJA1抗體;DNAJA1;DNAJA1 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

DNAJA1抗體—艾普蒂相關(guān)廠家報價

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