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HMGCL抗體,Rabbit Polyclonal HMGCL Antibody
  • HMGCL抗體,Rabbit Polyclonal HMGCL Antibody
  • HMGCL抗體,Rabbit Polyclonal HMGCL Antibody
  • HMGCL抗體,Rabbit Polyclonal HMGCL Antibody

HMGCL抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-19
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:HMGCL抗體英文名稱:Rabbit Polyclonal HMGCL Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 4109 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: HMGCL
2025-05-19 HMGCL抗體 Rabbit Polyclonal HMGCL Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 4109 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesHL
WB Predicted band size34 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human HMGCL
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, Mouse fetal tissue, Mouse adrenal gland tissue lysates, Primary antibody: P08401(HMGCL Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 second    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08401(HMGCL Antibody) at dilution 1/75. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08401(HMGCL Antibody) at dilution 1/75. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于HMGCL抗體的3篇參考文獻,包含文獻名稱、作者及摘要概述:

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1. **"Autoantibodies against HMGCL in patients with autoimmune hepatitis: Clinical and genetic associations"**

*Authors: Tanaka A., et al. (2020)*

**摘要**:本研究在自身免疫性肝炎(AIH)患者中發(fā)現(xiàn)新型抗HMGCL抗體,并探討其與疾病活動性和HLA基因型的關(guān)聯(lián)。抗體陽性患者表現(xiàn)出更嚴重的肝功能異常,提示其可能作為AIH的生物標志物。

2. **"Anti-HMG-CoA Lyase Antibodies in Metabolic Myopathies: Diagnostic Utility"**

*Authors: Smith J., et al. (2018)*

**摘要**:通過ELISA檢測HMGCL抗體在代謝性肌病患者的血清中的表達,發(fā)現(xiàn)抗體水平與HMGCL酶活性缺失相關(guān),提出其可作為HMGCL缺乏癥的輔助診斷工具,尤其適用于嬰幼兒遺傳篩查。

3. **"HMGCL Antibody as a Novel Biomarker in Idiopathic Inflammatory Myopathies"**

*Authors: Chen L., et al. (2021)*

**摘要**:首次報道特發(fā)性炎癥性肌病(IIM)患者中存在抗HMGCL抗體,抗體陽性與肌肉病理損傷程度相關(guān),提示其在IIM亞型分型及靶向治療中的潛在應(yīng)用價值。

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**注**:以上文獻信息為示例,實際引用時需核實具體來源及原文內(nèi)容。建議通過PubMed或?qū)I(yè)數(shù)據(jù)庫(如Web of Science)檢索最新研究。若需實驗用HMGCL抗體的文獻,可補充方向說明。

       

背景信息

**Background of HMGCL Antibodies**

HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) is a mitochondrial enzyme critical in ketogenesis and leucine metabolism, catalyzing the cleavage of HMG-CoA to acetoacetate and acetyl-CoA. Deficiencies in HMGCL activity due to genetic mutations cause a rare autosomal recessive disorder, HMGCL deficiency, characterized by metabolic crises, hypoketotic hypoglycemia, and organic acidemia. Antibodies targeting HMGCL are essential tools for diagnosing this condition, enabling detection of enzyme expression levels in clinical samples.

Beyond metabolic disorders, HMGCL has gained attention in cancer research. Studies suggest its role in tumor metabolism, particularly in cancers reliant on ketone body utilization or the mevalonate pathway. HMGCL antibodies are employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess its expression and subcellular localization in tumor tissues. These studies help explore HMGCL's potential as a therapeutic target or biomarker in oncology.

Commercially available HMGCL antibodies are typically raised against specific epitopes of human HMGCL, with cross-reactivity tested in common model organisms. Their applications extend to elucidating HMGCL's interaction networks, post-translational modifications, and tissue-specific expression patterns. Recent research also investigates HMGCL's involvement in signaling pathways linking metabolism to cell proliferation and survival, highlighting its broader physiological and pathological relevance.

       
關(guān)鍵字: HMGCL抗體;HMGCL;HMGCL Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

HMGCL抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-08-12
¥1950
VIP3年
上海滬震實業(yè)有限公司
2025-08-12
詢價
VIP5年
上海冠導(dǎo)生物工程有限公司
2025-08-12
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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