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     The image is immunohistochemistry of paraffin-embedded Human renal cancer tissue using P07017(COX10 Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

The COX10 antibody is a crucial tool in studying the function and expression of the COX10 protein, which plays a pivotal role in mitochondrial energy production. COX10 (cytochrome c oxidase assembly factor 10) is a nuclear-encoded enzyme essential for the biosynthesis of cytochrome c oxidase (COX), the terminal enzyme in the mitochondrial electron transport chain (ETC). Specifically, COX10 catalyzes the conversion of protoheme to heme O, a critical step in the synthesis of heme A, a prosthetic group required for COX enzymatic activity. Dysregulation of COX10 has been linked to mitochondrial disorders, neurodegenerative diseases, and cancer, making it a biomarker of interest in metabolic and pathological studies.

Antibodies targeting COX10 enable researchers to detect and quantify its expression in tissues or cultured cells, often via techniques like Western blotting, immunohistochemistry, or immunofluorescence. These antibodies help investigate COX10's role in mitochondrial dysfunction, oxidative phosphorylation efficiency, and cellular responses to stress. Validated COX10 antibodies are particularly valuable in diagnosing mitochondrial diseases (e.g., Leigh syndrome) and exploring therapeutic strategies targeting mitochondrial metabolism. However, specificity and cross-reactivity challenges require careful validation using knockout controls or siRNA-based approaches. As COX10 levels often correlate with mitochondrial health, its antibody serves as a key reagent in studies linking energy metabolism to disease mechanisms, aging, and apoptosis.