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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06640(GPR180 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

GPR180. also known as G-protein coupled receptor 180. is a member of the adhesion class of G-protein coupled receptors (GPCRs), a large family of cell surface proteins involved in signal transduction. Initially identified through genomic studies, GPR180 remains an understudied orphan receptor, meaning its endogenous ligand and precise physiological roles are not fully elucidated. It is characterized by a long extracellular N-terminal domain, a feature common to adhesion GPCRs, which may mediate cell-cell or cell-matrix interactions. Emerging research suggests GPR180 is expressed in various tissues, including the vascular system, lungs, and kidneys, with potential roles in angiogenesis, tissue remodeling, and metabolic regulation. Its involvement in diseases such as cancer, fibrosis, and cardiovascular disorders has been hypothesized but requires further validation.

GPR180 antibodies are essential tools for investigating the receptor's expression, localization, and function. These antibodies are typically developed against specific epitopes in the extracellular or intracellular domains of GPR180 and are validated for applications like Western blotting, immunohistochemistry, and flow cytometry. Due to the receptor's orphan status and low expression levels in many tissues, antibody specificity is critical to avoid cross-reactivity with other GPCRs. Recent studies using GPR180 antibodies have linked the receptor to signaling pathways involving cAMP and MAPK, suggesting its potential interplay with cellular proliferation and migration. However, the functional relevance of GPR180 in health and disease remains an active area of research, necessitating reliable antibody reagents for mechanistic exploration.