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FBXL4抗體,Rabbit Polyclonal FBXL4 Antibody
  • FBXL4抗體,Rabbit Polyclonal FBXL4 Antibody
  • FBXL4抗體,Rabbit Polyclonal FBXL4 Antibody
  • FBXL4抗體,Rabbit Polyclonal FBXL4 Antibody

FBXL4抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-18
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:FBXL4抗體英文名稱:Rabbit Polyclonal FBXL4 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3148 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): FBXL4
2025-05-18 FBXL4抗體 Rabbit Polyclonal FBXL4 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3148 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesFBL4; FBL5; MTDPS13
WB Predicted band size70 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human FBXL4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: LOVO cell lysate, Primary antibody: P06508(FBXL4 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P06508(FBXL4 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P06508(FBXL4 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于FBXL4抗體的3篇參考文獻(xiàn)(示例為虛構(gòu),實(shí)際文獻(xiàn)需通過(guò)數(shù)據(jù)庫(kù)查詢確認(rèn)):

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1. **文獻(xiàn)名稱**: *FBXL4 mutations cause mitochondrial encephalopathy via impaired mitochondrial DNA maintenance*

**作者**: Antoun G, et al.

**摘要**: 本研究通過(guò)Western blot和免疫熒光技術(shù),使用FBXL4特異性抗體分析患者成纖維細(xì)胞,發(fā)現(xiàn)FBXL4突變導(dǎo)致線粒體DNA耗竭及呼吸鏈功能缺陷,揭示了其在維持線粒體基因組穩(wěn)定性中的作用。

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2. **文獻(xiàn)名稱**: *FBXL4 regulates mitochondrial autophagy and cell survival under metabolic stress*

**作者**: Duan S, et al.

**摘要**: 通過(guò)免疫共沉淀(IP)和免疫熒光顯微術(shù),作者發(fā)現(xiàn)FBXL4抗體標(biāo)記的蛋白在營(yíng)養(yǎng)缺乏條件下調(diào)控線粒體自噬,并影響細(xì)胞凋亡,提示其作為代謝應(yīng)激反應(yīng)的關(guān)鍵因子。

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3. **文獻(xiàn)名稱**: *Structural and functional analysis of FBXL4 in the SKP1-CUL1-F-box protein complex*

**作者**: Gai X, et al.

**摘要**: 利用FBXL4抗體進(jìn)行蛋白質(zhì)印跡和免疫組化,研究揭示了FBXL4作為SCF泛素連接酶復(fù)合物成員的分子結(jié)構(gòu),及其在泛素化降解特定線粒體蛋白中的機(jī)制。

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如需具體文獻(xiàn),建議通過(guò)PubMed或Google Scholar以“FBXL4 antibody” + “Western blot/IF/function”等關(guān)鍵詞檢索近年研究。

       

背景信息

The FBXL4 antibody is a research tool designed to detect and study the F-box and leucine-rich repeat protein 4 (FBXL4), a member of the F-box protein family. FBXL4 functions as a substrate-recognition component of the Skp1-Cul1-F-box (SCF) ubiquitin ligase complex, which mediates protein ubiquitination and subsequent degradation via the proteasome. This protein plays a critical role in mitochondrial homeostasis, energy metabolism, and cellular stress responses. Mutations in the FBXL4 gene are linked to mitochondrial disorders, such as encephalomyopathic mitochondrial DNA depletion syndrome (MTDPS13), characterized by severe neurological and metabolic abnormalities.

Antibodies targeting FBXL4 are widely used in biomedical research to investigate its expression, localization, and interaction partners in various tissues and disease models. They are essential in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein levels and subcellular distribution. FBXL4 antibodies also aid in studying its regulatory roles in mitochondrial dynamics, apoptosis, and metabolic pathways. Given its association with mitochondrial dysfunction and cancer progression, these antibodies are valuable for exploring therapeutic targets and molecular mechanisms underlying related diseases. Commercial FBXL4 antibodies are typically validated for specificity and sensitivity to ensure reliable experimental outcomes.

       
關(guān)鍵字: FBXL4抗體;FBXL4;FBXL4 Antibody;

公司簡(jiǎn)介

是一家科研、開(kāi)發(fā)、生產(chǎn)和銷(xiāo)售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤(pán)

FBXL4抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價(jià)
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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