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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P06399(DRGX Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The DRGX antibody targets the Dorsal Root Ganglion Homeobox Protein (DRGX), also known as PRRXL1. a transcription factor critical in sensory neuron development. Discovered for its specific expression in dorsal root ganglia (DRG), DRGX plays a role in regulating the differentiation and functional maturation of nociceptive neurons, which are essential for pain perception. It belongs to the PRRX family of homeobox proteins, which are involved in embryonic patterning and tissue-specific gene regulation. Research has shown that DRGX is selectively expressed in small-diameter DRG neurons, particularly those associated with nociception and thermosensation, making it a biomarker for studying pain pathways.

The DRGX antibody has become a valuable tool in neuroscience research, enabling the identification and characterization of DRGX-expressing neurons in both developmental and pathological contexts. Studies using this antibody have explored its involvement in neuropathic pain, inflammatory pain, and nerve injury models, shedding light on molecular mechanisms underlying chronic pain conditions. Additionally, DRGX's regulatory role in axon guidance and synaptic connectivity has been investigated, linking it to sensory circuit assembly.

As a research reagent, the DRGX antibody is widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize spatial and temporal expression patterns. Its application continues to advance understanding of sensory biology and potential therapeutic targets for pain management.