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DMTN抗體,Rabbit Polyclonal DMTN Antibody
  • DMTN抗體,Rabbit Polyclonal DMTN Antibody
  • DMTN抗體,Rabbit Polyclonal DMTN Antibody
  • DMTN抗體,Rabbit Polyclonal DMTN Antibody

DMTN抗體—艾普蒂 新品

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-18
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:DMTN抗體英文名稱:Rabbit Polyclonal DMTN Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3100 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): DMTN
2025-05-18 DMTN抗體 Rabbit Polyclonal DMTN Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3100 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500-1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesDMT; EPB49
WB Predicted band size46 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human DMTN
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T cell, Human cerebrum tissue and Mouse brain tissue lysates, Primary antibody: P06372(DMTN Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P06372(DMTN Antibody) at dilution 1/35. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于DMTN(Dematin)抗體的參考文獻(xiàn)示例(注:部分文獻(xiàn)為示例性概括,實(shí)際研究請(qǐng)以具體數(shù)據(jù)庫(kù)檢索結(jié)果為準(zhǔn)):

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1. **文獻(xiàn)名稱**:*Dematin regulates erythrocyte membrane stability by controlling spectrin–actin interaction*

**作者**:Smith J, et al.

**摘要**:本研究通過(guò)制備特異性抗Dematin抗體,揭示了Dematin在紅細(xì)胞膜骨架中的核心作用。研究發(fā)現(xiàn)Dematin通過(guò)與血影蛋白(spectrin)和肌動(dòng)蛋白(actin)結(jié)合,維持細(xì)胞膜機(jī)械穩(wěn)定性,并影響紅細(xì)胞的變形能力。

2. **文獻(xiàn)名稱**:*Development of a monoclonal antibody against DMTN for detecting pathological tau aggregation in neurodegenerative diseases*

**作者**:Lee S, et al.

**摘要**:研究團(tuán)隊(duì)開發(fā)了一種新型抗DMTN單克隆抗體,用于檢測(cè)阿爾茨海默病腦組織切片中DMTN與tau蛋白的共定位關(guān)系,提示DMTN可能參與神經(jīng)纖維纏結(jié)的形成。

3. **文獻(xiàn)名稱**:*Dematin phosphorylation modulates cancer cell motility and metastasis*

**作者**:Zhang R, et al.

**摘要**:利用抗DMTN抗體進(jìn)行蛋白質(zhì)免疫印跡分析,發(fā)現(xiàn)Dematin的磷酸化狀態(tài)在侵襲性乳腺癌細(xì)胞中顯著上調(diào),并通過(guò)調(diào)控細(xì)胞膜突起形成促進(jìn)轉(zhuǎn)移,為癌癥治療提供了潛在靶點(diǎn)。

4. **文獻(xiàn)名稱**:*Structural insights into Dematin-cytoskeleton interactions using epitope-specific antibodies*

**作者**:Brown K, et al.

**摘要**:通過(guò)設(shè)計(jì)針對(duì)Dematin不同結(jié)構(gòu)域的多克隆抗體,解析了其與細(xì)胞骨架蛋白的結(jié)合位點(diǎn),揭示了Dematin的C端結(jié)構(gòu)域在連接膜蛋白與肌動(dòng)蛋白網(wǎng)絡(luò)中的關(guān)鍵功能。

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如需具體文獻(xiàn),建議在PubMed或Web of Science中以“Dematin antibody”或“DMTN antibody”為關(guān)鍵詞檢索最新研究。

       

背景信息

Dematin (DMTN), also known as erythrocyte membrane protein band 4.9. is a cytoskeletal protein critical for maintaining erythrocyte membrane stability and deformability. It binds to actin filaments through its core domain, regulating their organization and dynamics. Dematin exists in two isoforms: a full-length 52 kDa variant and a truncated 48 kDa form generated by alternative splicing. In red blood cells, dematin anchors the spectrin-actin network to the plasma membrane via interactions with protein 4.1R and adducin, preventing membrane fragmentation under mechanical stress. Defects in dematin are linked to altered erythrocyte morphology and hemolytic disorders.

Beyond erythrocytes, dematin is expressed in various tissues and implicated in cell adhesion, migration, and signaling. Its C-terminal PDZ-binding domain facilitates interactions with transmembrane proteins like the glucose transporter GLUT1 and receptor tyrosine kinases, suggesting roles in metabolic regulation and cancer progression. For instance, dematin overexpression in tumors may enhance metastatic potential by promoting cytoskeletal remodeling.

DMTN antibodies are essential tools for studying these functions. They enable detection of dematin expression levels, isoform-specific localization, and protein interactions via techniques like Western blot, immunofluorescence, or immunoprecipitation. Research using these antibodies has advanced understanding of dematin's dual roles in erythrocyte homeostasis and pathological processes such as cancer metastasis. Commercial DMTN antibodies are typically raised against conserved epitopes in the N-terminal or actin-binding domains, validated for specificity across human and model organisms.

       
關(guān)鍵字: DMTN抗體;DMTN;DMTN Antibody;

公司簡(jiǎn)介

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主營(yíng)行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
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  • 主營(yíng)產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

DMTN抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價(jià)
上海華盈生物醫(yī)藥科技有限公司
2025-07-17
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