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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P05848(SFRP2 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The secreted frizzled-related protein 2 (SFRP2) antibody is a tool used to study the biological role of SFRP2. a glycoprotein belonging to the SFRP family that modulates Wnt signaling pathways. SFRP2 acts as a Wnt antagonist by binding to Wnt ligands or frizzled receptors, thereby regulating cell proliferation, differentiation, and tissue homeostasis. It plays critical roles in embryonic development, bone formation, angiogenesis, and tissue repair. Dysregulation of SFRP2 has been implicated in various diseases, including cancer, fibrosis, and cardiovascular disorders. In cancer, SFRP2 exhibits dual roles—acting as a tumor suppressor in some contexts (e.g., inhibiting Wnt/β-catenin signaling) or promoting tumor progression in others (e.g., enhancing matrix metalloproteinase activity or angiogenesis).

SFRP2 antibodies are widely utilized in research to detect protein expression levels, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate SFRP2's involvement in disease mechanisms and its potential as a therapeutic target. For instance, neutralizing SFRP2 with antibodies has shown promise in preclinical models for inhibiting tumor growth or fibrosis. However, challenges remain, including understanding context-dependent functions and optimizing antibody specificity to avoid off-target effects. Ongoing studies aim to refine SFRP2-targeted therapies and diagnostic applications, leveraging its dual regulatory nature in Wnt signaling pathways.