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SPAM1抗體,Rabbit Polyclonal SPAM1 Antibody
  • SPAM1抗體,Rabbit Polyclonal SPAM1 Antibody
  • SPAM1抗體,Rabbit Polyclonal SPAM1 Antibody
  • SPAM1抗體,Rabbit Polyclonal SPAM1 Antibody

SPAM1抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-18
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SPAM1抗體英文名稱:Rabbit Polyclonal SPAM1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2944 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): SPAM1
2025-05-18 SPAM1抗體 Rabbit Polyclonal SPAM1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2944 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/10-1/50 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCK18; CYK18; KRT18
Entrez GeneID16668
WB Predicted band sizeCalculated MW: 48 kDa; Observed MW: 48 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenRecombinant protein of mouse Cytokeratin 18
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

+ +

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       Western blot analysis of Keratin 18 in Hela, K562 lysates using Cytokeratin 18 antibody.    


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       Immunocytochemistry analysis of Cytokeratin 18(green) in Hela using Cytokeratin 18 antibody,and DAPI(blue)    


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       Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma using Cytokeratin 18 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.    


           

參考文獻(xiàn)

以下是關(guān)于SPAM1抗體的3-4篇參考文獻(xiàn)的簡要概括(文獻(xiàn)標(biāo)題與內(nèi)容為模擬示例,實(shí)際文獻(xiàn)需通過數(shù)據(jù)庫檢索確認(rèn)):

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1. **文獻(xiàn)名稱**:*SPAM1/PH-20 localization in sperm and its role in hyaluronidase activity during fertilization*

**作者**:Cherr G.N. et al.

**摘要**:研究利用SPAM1特異性抗體,通過免疫熒光技術(shù)定位SPAM1蛋白在精子頂體區(qū)域的表達(dá),證實(shí)其透明質(zhì)酸酶活性對卵子透明帶穿透的關(guān)鍵作用,抗體阻斷實(shí)驗(yàn)顯著降低體外受精率。

2. **文獻(xiàn)名稱**:*Anti-SPAM1 monoclonal antibody inhibits tumor metastasis via targeting hyaluronan degradation*

**作者**:Zhang Y. et al.

**摘要**:開發(fā)了一種高親和力SPAM1單克隆抗體,發(fā)現(xiàn)其可通過抑制SPAM1的透明質(zhì)酸酶活性,減少腫瘤細(xì)胞外基質(zhì)降解,從而在小鼠模型中顯著降低乳腺癌細(xì)胞的轉(zhuǎn)移潛能。

3. **文獻(xiàn)名稱**:*SPAM1 as a potential immune contraceptive target: antibody-mediated fertility reduction in primates*

**作者**:Primakoff P. et al.

**摘要**:評估SPAM1抗體在食蟹猴中的避孕效果,發(fā)現(xiàn)抗體注射可導(dǎo)致精子活力下降及透明帶穿透能力喪失,為非激素避孕策略提供實(shí)驗(yàn)依據(jù)。

4. **文獻(xiàn)名稱**:*Expression profiling of SPAM1 in gastric cancer and its correlation with patient prognosis*

**作者**:Li X. et al.

**摘要**:通過免疫組化結(jié)合SPAM1抗體,發(fā)現(xiàn)SPAM1在胃癌組織中高表達(dá),且與腫瘤分期和患者生存率負(fù)相關(guān),提示其作為預(yù)后標(biāo)志物的潛力。

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建議通過PubMed或Web of Science檢索關(guān)鍵詞“SPAM1 antibody”“PH-20 antibody”獲取真實(shí)文獻(xiàn)。

       

背景信息

The SPAM1 (Sperm Adhesion Molecule 1) antibody targets the SPAM1 protein, also known as PH-20. a glycosylphosphatidylinositol (GPI)-anchored membrane protein primarily associated with sperm function. Discovered in the 1980s, SPAM1/PH-20 is expressed in the testis and localizes to the sperm's acrosomal membrane and plasma membrane. It exhibits hyaluronidase activity, critical for sperm penetration through the hyaluronic acid-rich extracellular matrix of the oocyte during fertilization. This dual enzymatic and adhesion role makes SPAM1 essential for reproductive biology.

SPAM1 antibodies are widely used in research to study sperm maturation, fertilization mechanisms, and infertility. They help detect SPAM1 expression patterns, assess its enzymatic function, and explore its role in pathologies like male infertility or certain cancers where SPAM1 is aberrantly expressed. Monoclonal and polyclonal antibodies against SPAM1 have also been investigated for contraceptive development, aiming to block its hyaluronidase activity or sperm-egg binding.

Additionally, SPAM1's homology with HYAL5 and its presence in somatic tissues (e.g., some tumors) have spurred interest in its oncogenic potential. Antibodies here aid in elucidating SPAM1's involvement in cancer metastasis via hyaluronan degradation. Overall, SPAM1 antibodies serve as vital tools in reproductive health, cancer research, and therapeutic innovation.

       
關(guān)鍵字: SPAM1抗體;SPAM1;SPAM1 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

SPAM1抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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