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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HEPG2 and 231 cell, Primary antibody: P05757(EGR2 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P05757(EGR2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The EGR2 (Early Growth Response 2) antibody is a tool used to detect and study the EGR2 protein, a transcription factor belonging to the early growth response (EGR) family. EGR2 plays critical roles in cellular differentiation, myelination of peripheral nerves, and immune regulation. It contains a zinc-finger DNA-binding domain, enabling it to regulate target genes by binding to specific promoter regions. Mutations in the *EGR2* gene are linked to inherited neuropathies such as Charcot-Marie-Tooth disease (CMT) and Dejerine-Sottas syndrome, highlighting its importance in peripheral nerve development. In immunology, EGR2 is expressed in T cells, where it modulates tolerance and suppresses excessive immune responses, implicating it in autoimmune disorders like systemic lupus erythematosus (SLE).

Antibodies against EGR2 are widely used in research to investigate its expression, localization, and function via techniques like Western blotting, immunohistochemistry, and flow cytometry. They help identify dysregulated EGR2 in disease models, offering insights into pathogenesis or therapeutic targets. Commercial EGR2 antibodies are typically validated for specificity in human, mouse, or rat samples. Researchers also explore its role in cancer, as EGR2 may act as a tumor suppressor or promoter depending on context. Overall, EGR2 antibodies serve as essential reagents in neuroscience, immunology, and oncology studies, bridging molecular mechanisms with clinical applications.