The KRTAP11-1 (Keratin-Associated Protein 11-1) gene encodes a member of the keratin-associated protein (KAP) family, which plays a structural role in hair and nail formation by interacting with keratin intermediate filaments. These proteins contribute to the mechanical strength and flexibility of hair through disulfide bond cross-linking. KRTAP11-1 is part of the high sulfur KAP group, localized on chromosome 21q22.1. and its expression is primarily restricted to the hair follicle cortex.
Antibodies targeting KRTAP11-1 are tools used to investigate its expression, localization, and function in hair biology and related disorders. They are typically produced in immunized hosts (e.g., rabbits or mice) using synthetic peptides or recombinant proteins as antigens. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding studies on hair shaft abnormalities, genetic variations (e.g., polymorphisms linked to hair traits), and diseases like monilethrix or hypotrichosis.
While research on KRTAP11-1 remains limited compared to other KAPs, its antibodies contribute to understanding hair keratinization mechanisms and potential therapeutic targets for hair disorders. Commercial availability varies, with some suppliers offering polyclonal or monoclonal options for experimental use. Validation data, including specificity and cross-reactivity, are critical for reliable application in research contexts.