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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P05615(PCDHA6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The PCDHA6 antibody is a research tool designed to detect protocadherin alpha 6 (PCDHA6), a member of the protocadherin alpha gene cluster. Protocadherins are transmembrane proteins critical for neural development, synaptic specificity, and cell-cell adhesion in the central nervous system. The alpha, beta, and gamma clusters encode diverse cadherin-like proteins that mediate homophilic interactions, enabling neurons to distinguish themselves during circuit formation. PCDHA6. specifically, is part of the alpha cluster, which undergoes stochastic gene expression to generate single-neuron identity, a mechanism thought to underlie neuronal self-avoidance and connectivity.

Antibodies targeting PCDHA6 are used to study its expression patterns, localization, and functional roles in development or disease. They are validated in assays like Western blotting, immunohistochemistry, or immunofluorescence. Research suggests protocadherins may contribute to neurodevelopmental disorders, and PCDHA6 dysregulation has been tentatively linked to cancer progression, though its precise role remains under investigation. The specificity of PCDHA6 antibodies is crucial due to high homology among protocadherin family members. Proper validation, including knockout controls, ensures reliable detection. These tools aid in unraveling PCDHA6's contributions to neural diversity, tissue organization, and potential disease pathways.