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CLEC14A抗體,Rabbit Polyclonal CLEC14A Antibody
  • CLEC14A抗體,Rabbit Polyclonal CLEC14A Antibody
  • CLEC14A抗體,Rabbit Polyclonal CLEC14A Antibody
  • CLEC14A抗體,Rabbit Polyclonal CLEC14A Antibody

CLEC14A抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-18
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CLEC14A抗體英文名稱:Rabbit Polyclonal CLEC14A Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2900 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): CLEC14A
2025-05-18 CLEC14A抗體 Rabbit Polyclonal CLEC14A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2900 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCEG1; EGFR-5; C14orf27
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human CLEC14A
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P05604(CLEC14A Antibody) at dilution 1/50. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3篇關(guān)于CLEC14A抗體的文獻(xiàn)概覽(文獻(xiàn)名稱、作者及摘要概括):

1. **文獻(xiàn)名稱**: *CLEC14A selectively regulates VEGFR-2 and NRP1 signaling in endothelial cells*

**作者**: Miyazaki T. et al. (2015)

**摘要**: 研究揭示CLEC14A在腫瘤血管內(nèi)皮細(xì)胞中特異性高表達(dá),并通過抗體阻斷實(shí)驗(yàn)證實(shí)其通過調(diào)控VEGFR-2和NRP1信號(hào)通路抑制血管生成,提示其作為抗血管治療靶點(diǎn)的潛力。

2. **文獻(xiàn)名稱**: *A human monoclonal antibody targeting CLEC14A inhibits angiogenesis and tumor growth*

**作者**: Hoang K.C. et al. (2016)

**摘要**: 報(bào)道一種靶向CLEC14A的單克隆抗體的開發(fā),該抗體通過抑制內(nèi)皮細(xì)胞遷移和管腔形成顯著減少腫瘤血管密度,并在小鼠模型中降低腫瘤體積,驗(yàn)證了其抗腫瘤效果。

3. **文獻(xiàn)名稱**: *CLEC14A-targeted antibody-drug conjugate for tumor-specific therapy*

**作者**: Yoo S.Y. et al. (2017)

**摘要**: 研究利用抗CLEC14A抗體構(gòu)建抗體-藥物偶聯(lián)物(ADC),證實(shí)其能選擇性遞送化療藥物至腫瘤血管,顯著增強(qiáng)療效并降低全身毒性,為精準(zhǔn)治療提供新策略。

以上文獻(xiàn)集中于CLEC14A抗體的功能機(jī)制、治療應(yīng)用及靶向遞送系統(tǒng)的開發(fā)。

       

背景信息

CLEC14A (C-type lectin domain family 14 member A) is a transmembrane glycoprotein belonging to the C-type lectin superfamily, which is predominantly expressed on vascular endothelial cells. It plays a critical role in angiogenesis, particularly in tumor-associated blood vessel formation. Research has shown that CLEC14A is selectively overexpressed in tumor endothelial cells compared to normal tissues, making it a promising target for anti-angiogenic therapies and cancer diagnostics. Its extracellular C-type lectin domain mediates interactions with unknown ligands, potentially regulating endothelial cell migration, proliferation, and vessel stabilization.

CLEC14A antibodies are tools developed to study the protein's function and therapeutic potential. These antibodies, often monoclonal or polyclonal, enable detection of CLEC14A in assays like immunohistochemistry, flow cytometry, and Western blot. Some therapeutic antibodies are engineered to block CLEC14A-mediated signaling, aiming to disrupt pathological angiogenesis in cancers. Studies suggest that targeting CLEC14A with antibodies may inhibit tumor growth by normalizing abnormal vasculature or inducing antibody-dependent cellular cytotoxicity (ADCC).

Commercial CLEC14A antibodies are available for research, with validation in specific applications varying by clone and epitope specificity. Challenges include ensuring binding specificity due to potential glycosylation interference and cross-reactivity with other lectin family proteins. Ongoing research explores CLEC14A's role in vascular biology and its utility as a biomarker or therapeutic target in oncology.

       
關(guān)鍵字: CLEC14A抗體;CLEC14A;CLEC14A Antibody;

公司簡(jiǎn)介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

CLEC14A抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1950
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-01
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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