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SMS抗體,Rabbit Polyclonal SMS Antibody
  • SMS抗體,Rabbit Polyclonal SMS Antibody
  • SMS抗體,Rabbit Polyclonal SMS Antibody
  • SMS抗體,Rabbit Polyclonal SMS Antibody

SMS抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-16
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產(chǎn)品詳情

中文名稱:SMS抗體英文名稱:Rabbit Polyclonal SMS Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2296 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): SMS
2025-05-16 SMS抗體 Rabbit Polyclonal SMS Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2296 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesSRS; SpS; MRSR; SPMSY
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human SMS
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P02682(SMS Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P02682(SMS Antibody) at dilution 1/70. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于SMS(鞘磷脂合成酶)抗體的參考文獻(xiàn)示例,包含文獻(xiàn)名稱、作者及摘要概括:

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1. **文獻(xiàn)名稱**:*Role of sphingomyelin synthase 1 (SMS1) in ceramide homeostasis and apoptosis*

**作者**:Yamaoka S, Miyaji M, Kitano T, et al.

**摘要**:本研究利用特異性SMS1抗體探究鞘磷脂合成酶1在細(xì)胞凋亡中的作用。發(fā)現(xiàn)SMS1缺失導(dǎo)致鞘磷脂(SM)減少和神經(jīng)酰胺(Cer)積累,激活線粒體凋亡通路,提示SMS1是維持脂質(zhì)平衡的關(guān)鍵因子。

2. **文獻(xiàn)名稱**:*Sphingomyelin synthase 2 deficiency attenuates atherosclerosis in mice*

**作者**:Huitema K, van den Dikkenberg J, Brouwers JF, et al.

**摘要**:通過(guò)SMS2抗體檢測(cè)小鼠模型中SMS2的表達(dá),發(fā)現(xiàn)SMS2敲除可減少動(dòng)脈粥樣硬化斑塊形成,其機(jī)制與調(diào)節(jié)脂質(zhì)代謝和炎癥因子分泌相關(guān),為治療心血管疾病提供新靶點(diǎn)。

3. **文獻(xiàn)名稱**:*Sphingomyelin synthase activity regulates viral entry and lipid raft dynamics*

**作者**:Tafesse FG, Sanyal S, Ashour J, et al.

**摘要**:利用SMS抗體研究病毒入侵機(jī)制,發(fā)現(xiàn)SMS活性影響宿主細(xì)胞膜脂筏結(jié)構(gòu),抑制SMS可阻斷HIV等包膜病毒進(jìn)入,提示靶向SMS或成為抗病毒治療策略。

4. **文獻(xiàn)名稱**:*Antibody-based profiling of sphingomyelin synthase in neurodegenerative disorders*

**作者**:Li Z, Hailemariam TK, Zhou H, et al.

**摘要**:通過(guò)免疫組化與SMS抗體分析阿爾茨海默病腦組織,發(fā)現(xiàn)SMS表達(dá)水平與β-淀粉樣蛋白沉積呈負(fù)相關(guān),提示鞘磷脂代謝異常可能參與神經(jīng)退行性病變進(jìn)程。

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**注**:以上文獻(xiàn)信息為示例性概括,具體內(nèi)容請(qǐng)通過(guò)PubMed或Google Scholar檢索DOI獲取全文。建議結(jié)合關(guān)鍵詞“sphingomyelin synthase antibody”+研究領(lǐng)域(如疾病名稱)進(jìn)一步篩選近期研究。

       

背景信息

SMS antibodies target sphingomyelin synthase (SMS), a key enzyme in sphingolipid metabolism that catalyzes the conversion of ceramide and phosphatidylcholine into sphingomyelin and diacylglycerol. Sphingomyelin is a critical component of cell membranes, while its metabolic byproducts, such as ceramide and sphingosine-1-phosphate, function as bioactive signaling molecules involved in cell proliferation, apoptosis, and stress responses. Dysregulation of SMS activity has been linked to metabolic disorders, cancer, and neurodegenerative diseases, driving interest in developing SMS-specific antibodies for research and therapeutic purposes.

These antibodies enable the detection, localization, and quantification of SMS isoforms (SMS1 and SMS2) in cellular and tissue samples, aiding studies on their distinct roles in lipid homeostasis and disease mechanisms. For example, SMS1 is primarily localized in the Golgi apparatus, while SMS2 associates with the plasma membrane, reflecting divergent biological functions. Recent advances in monoclonal antibody technology have improved specificity and sensitivity, supporting applications in immunohistochemistry, Western blotting, and flow cytometry.

Research utilizing SMS antibodies has highlighted their potential as biomarkers or therapeutic targets, particularly in cancers where altered sphingolipid metabolism promotes tumor survival. Further exploration of SMS inhibition or modulation via antibody-based strategies could offer novel treatments for metabolic and oncological conditions.

       
關(guān)鍵字: SMS抗體;SMS;SMS Antibody;

公司簡(jiǎn)介

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主營(yíng)行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
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  • 主營(yíng)產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤(pán)

SMS抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1950
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-01
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-07-30
詢價(jià)
VIP1年
上海賓穗生物科技有限公司
2025-08-02
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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