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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain and Human fetal liver tissue lysates, Primary antibody: P02601(DCTD Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

DCTD (dCMP deaminase) is an enzyme encoded by the *DCTD* gene, playing a critical role in pyrimidine nucleotide metabolism by catalyzing the deamination of deoxycytidine monophosphate (dCMP) to deoxyuridine monophosphate (dUMP). This reaction is essential for maintaining balanced deoxynucleotide pools required for DNA synthesis and repair. Dysregulation of DCTD activity has been implicated in genomic instability and cancer progression, as altered nucleotide pools can lead to mutagenesis or impaired replication fidelity.

DCTD antibodies are immunological tools developed to detect and quantify DCTD protein expression in research and diagnostic contexts. These antibodies enable studies exploring DCTD's role in cellular proliferation, response to chemotherapy (e.g., gemcitabine, a nucleoside analog), and mechanisms of drug resistance in cancers. Overexpression of DCTD has been observed in certain malignancies, potentially influencing treatment outcomes by modulating the activation or detoxification of nucleoside-based therapies. Additionally, DCTD antibodies aid in elucidating its interaction with other enzymes in nucleotide metabolism pathways, such as thymidylate synthase. Validated in applications like Western blotting, immunohistochemistry, and ELISA, these antibodies contribute to both basic research and translational studies aiming to target nucleotide metabolism for anticancer strategies.