+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P02579(CYB5R4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The CYB5R4 antibody is a research tool designed to detect cytochrome b5 reductase 4 (CYB5R4), an enzyme belonging to the NADH-cytochrome b5 reductase family. CYB5R4 is involved in redox metabolism, facilitating electron transfer from NADH to cytochrome b5. which plays roles in lipid biosynthesis, drug metabolism, and cellular detoxification. Unlike other isoforms (e.g., CYB5R3), CYB5R4 is localized to the endoplasmic reticulum and mitochondria, suggesting unique regulatory functions in these organelles.

Antibodies targeting CYB5R4 are primarily used to study its expression, subcellular distribution, and interactions in various tissues and disease models. Research indicates that CYB5R4 may influence metabolic pathways, including fatty acid desaturation and cholesterol synthesis, and has been implicated in cancer progression, neurodegenerative disorders, and oxidative stress responses. For example, altered CYB5R4 levels have been observed in certain cancers, potentially affecting tumor cell survival and drug resistance.

These antibodies are typically validated for applications such as Western blotting, immunofluorescence, and immunohistochemistry. Their development often involves immunizing hosts with peptide antigens derived from conserved regions of the human CYB5R4 protein. Despite progress, the precise physiological and pathological roles of CYB5R4 remain under investigation, emphasizing the continued relevance of specific antibodies in elucidating its molecular mechanisms and therapeutic potential.