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BRSK1抗體,Rabbit Polyclonal BRSK1 Antibody
  • BRSK1抗體,Rabbit Polyclonal BRSK1 Antibody
  • BRSK1抗體,Rabbit Polyclonal BRSK1 Antibody
  • BRSK1抗體,Rabbit Polyclonal BRSK1 Antibody

BRSK1抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-16
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:BRSK1抗體英文名稱:Rabbit Polyclonal BRSK1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2219 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): BRSK1
2025-05-16 BRSK1抗體 Rabbit Polyclonal BRSK1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2219 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliaseshSAD1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human BRSK1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P02407(BRSK1 Antibody) at dilution 1/95. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P02407(BRSK1 Antibody) at dilution 1/95. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于BRSK1抗體的3篇參考文獻(xiàn)示例(注:部分內(nèi)容為示例性概括,實(shí)際文獻(xiàn)需通過學(xué)術(shù)數(shù)據(jù)庫進(jìn)一步驗(yàn)證):

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1. **文獻(xiàn)名稱**:*BRSK1 regulates neuronal polarity through phosphorylation of end-binding proteins*

**作者**:Lizhi, L. et al.

**摘要**:本研究利用BRSK1特異性抗體進(jìn)行免疫熒光和免疫印跡分析,揭示了BRSK1激酶通過磷酸化微管末端結(jié)合蛋白(EB1/EB3)調(diào)控神經(jīng)元軸突極性的分子機(jī)制??贵w驗(yàn)證顯示BRSK1在神經(jīng)元分化早期高表達(dá)并定位于生長錐。

2. **文獻(xiàn)名稱**:*Cell cycle-dependent localization of BRSK1 in mitotic progression*

**作者**:Gray, N.E. et al.

**摘要**:通過BRSK1抗體的亞細(xì)胞定位分析,發(fā)現(xiàn)BRSK1在有絲分裂中期定位于紡錘體極部,并在分裂結(jié)束后轉(zhuǎn)移至胞質(zhì)。研究提示BRSK1可能參與調(diào)控細(xì)胞周期退出,抗體特異性經(jīng)siRNA敲低實(shí)驗(yàn)驗(yàn)證。

3. **文獻(xiàn)名稱**:*Dysregulation of BRSK1 in glioblastoma correlates with poor prognosis*

**作者**:Smith, J.R. et al.

**摘要**:采用BRSK1抗體對(duì)膠質(zhì)母細(xì)胞瘤組織進(jìn)行免疫組化分析,發(fā)現(xiàn)BRSK1蛋白表達(dá)水平與腫瘤分級(jí)及患者生存率顯著相關(guān)。Western blot進(jìn)一步證實(shí)其在腫瘤樣本中的異常高表達(dá)。

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**提示**:以上文獻(xiàn)為示例,實(shí)際引用時(shí)建議通過PubMed或Google Scholar以關(guān)鍵詞“BRSK1 antibody”檢索最新研究,并核對(duì)抗體貨號(hào)及實(shí)驗(yàn)細(xì)節(jié)。

       

背景信息

The BRSK1 antibody is a tool used to detect BRSK1 (BR serine/threonine kinase 1), a protein encoded by the *BRSK1* gene in humans. BRSK1. also known as SAD-B or SAD1. belongs to the AMP-activated protein kinase (AMPK)-related kinase family and is predominantly expressed in the brain, particularly in neurons. It plays a critical role in regulating cell cycle progression, neuronal polarization, and synaptic vesicle trafficking. BRSK1 is activated by the tumor suppressor kinase LKB1 through phosphorylation, enabling its involvement in establishing neuronal polarity during development.

Antibodies against BRSK1 are widely used in neuroscience research to study its localization, expression levels, and interaction partners. They facilitate techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore BRSK1's role in neuronal differentiation, axon-dendrite specification, and potential links to neurological disorders. Studies suggest BRSK1 dysfunction may contribute to neurodegenerative diseases or brain tumors, though its precise mechanisms remain under investigation.

BRSK1 shares structural homology with its paralog BRSK2. but their tissue distribution and functional nuances differ. Commercially available BRSK1 antibodies are typically validated for specificity and sensitivity, often targeting conserved regions like the kinase domain. Researchers rely on these reagents to dissect BRSK1's signaling pathways, including its interplay with microtubule-associated proteins and involvement in autophagy or synaptic plasticity.

       
關(guān)鍵字: BRSK1抗體;BRSK1;BRSK1 Antibody;

公司簡(jiǎn)介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

BRSK1抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP5年
上海冠導(dǎo)生物工程有限公司
2025-08-02
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
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