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ATAD1抗體,Rabbit Polyclonal ATAD1 Antibody
  • ATAD1抗體,Rabbit Polyclonal ATAD1 Antibody
  • ATAD1抗體,Rabbit Polyclonal ATAD1 Antibody
  • ATAD1抗體,Rabbit Polyclonal ATAD1 Antibody

ATAD1抗體—艾普蒂

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-16
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ATAD1抗體英文名稱:Rabbit Polyclonal ATAD1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2214 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): ATAD1
2025-05-16 ATAD1抗體 Rabbit Polyclonal ATAD1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2214 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesAFDC1; FNP001; THORASE
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human ATAD1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Rat brain tissue, Mouse brain tissue and Human cerebrum tissue lysates, Primary antibody: P02369(ATAD1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 60 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P02369(ATAD1 Antibody) at dilution 1/65. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P02369(ATAD1 Antibody) at dilution 1/65. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于ATAD1抗體的3篇參考文獻(xiàn)及其摘要概括:

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1. **文獻(xiàn)名稱**:*ATPase family AAA domain-containing protein 1 (ATAD1) regulates mitochondrial fragmentation and neuronal survival*

**作者**:Chen et al.

**摘要**:該研究通過(guò)免疫印跡(Western blot)和免疫熒光技術(shù),利用ATAD1抗體證實(shí)了其在調(diào)控線粒體分裂中的作用。實(shí)驗(yàn)表明,ATAD1缺失導(dǎo)致線粒體過(guò)度碎片化,并誘發(fā)神經(jīng)元凋亡,提示其在線粒體動(dòng)態(tài)平衡中的關(guān)鍵功能。

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2. **文獻(xiàn)名稱**:*Thorase (ATAD1) modulates AMPA receptor recycling through its ATPase activity*

**作者**:Zhang et al.

**摘要**:研究利用ATAD1特異性抗體在小鼠腦組織中檢測(cè)Thorase蛋白表達(dá),發(fā)現(xiàn)其通過(guò)水解ATP調(diào)控AMPA受體的內(nèi)吞與再循環(huán)。敲除ATAD1后,突觸后受體穩(wěn)定性受損,提示其在突觸可塑性中的重要作用。

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3. **文獻(xiàn)名稱**:*ATAD1 as a novel player in protein quality control: Insights from antibody-based subcellular localization*

**作者**:Wang et al.

**摘要**:通過(guò)免疫共聚焦顯微鏡和免疫沉淀技術(shù),該文獻(xiàn)揭示了ATAD1抗體在追蹤蛋白降解途徑中的應(yīng)用。研究發(fā)現(xiàn)ATAD1與泛素-蛋白酶體系統(tǒng)相互作用,參與錯(cuò)誤折疊蛋白的清除,為神經(jīng)退行性疾病機(jī)制提供了新視角。

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以上研究均通過(guò)ATAD1抗體探索了該蛋白的生物學(xué)功能,涵蓋線粒體動(dòng)力學(xué)、突觸調(diào)控及蛋白質(zhì)量控制等領(lǐng)域。

       

背景信息

The ATAD1 antibody is a crucial tool for studying the ATPase family AAA domain-containing protein 1 (ATAD1), also known as Thorase. ATAD1 is a mitochondrial membrane-associated AAA+ ATPase that plays a key role in regulating mitochondrial dynamics and protein homeostasis. It is involved in the disassembly of mitochondrial membrane protein complexes, particularly mediating the removal of misfolded or excess proteins, such as the AMPA receptor subunit GluA1 in neurons. This function links ATAD1 to neuroprotection and neurodegenerative disorders like Alzheimer’s disease and Parkinson’s disease.

ATAD1 antibodies are widely used in research to detect and quantify ATAD1 expression via techniques such as Western blotting, immunohistochemistry, and immunoprecipitation. They help investigate ATAD1’s interaction with substrates, its ATPase activity, and its role in mitochondrial quality control. Studies using these antibodies have revealed ATAD1’s involvement in preventing neuronal excitotoxicity by regulating glutamate receptor turnover. Knockout mouse models and cell-based assays, supported by ATAD1 antibodies, highlight its essential role in maintaining mitochondrial integrity and cellular viability. Commercially available ATAD1 antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown. Research utilizing these tools continues to explore ATAD1’s broader implications in metabolic disorders, cancer, and aging-related pathologies.

       
關(guān)鍵字: ATAD1抗體;ATAD1;ATAD1 Antibody;

公司簡(jiǎn)介

是一家科研、開(kāi)發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊(cè)資本 20萬(wàn)人民幣
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:20萬(wàn)人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

ATAD1抗體—艾普蒂相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費(fèi)雪(杭州)醫(yī)學(xué)研究有限公司
2025-07-28
詢價(jià)
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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