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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P02193(PRELID1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The PRELID1 (PRELI Domain Containing 1) antibody is a tool used to study the PRELID1 protein, a member of the conserved PRELI family involved in mitochondrial function. PRELID1 is primarily localized to mitochondria and plays a critical role in phospholipid metabolism, particularly in the transfer of phosphatidic acid (PA) and phosphatidylserine (PS) between mitochondrial membranes. This process is essential for maintaining mitochondrial integrity, membrane dynamics, and apoptosis regulation. PRELID1 interacts with TRIAP1 (TP53-regulated inhibitor of apoptosis 1) to form a complex that facilitates lipid shuttling, influencing mitochondrial-dependent cell death pathways.

Antibodies targeting PRELID1 enable researchers to investigate its expression, localization, and interactions in various biological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore PRELID1's role in cellular processes, including energy metabolism, oxidative stress response, and cancer biology. Dysregulation of PRELID1 has been implicated in diseases like cancer, neurodegenerative disorders, and cardiovascular conditions, highlighting its potential as a therapeutic or diagnostic target. Studies using PRELID1 antibodies have also shed light on its tissue-specific expression patterns and post-translational modifications, contributing to a deeper understanding of mitochondrial lipid homeostasis and its broader physiological implications.