+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue and Rat brain tissue, Primary antibody: P02153(TPPP Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P02153(TPPP Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P02153(TPPP Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

TPPP (Tubulin Polymerization Promoting Protein) antibodies target a family of proteins involved in microtubule dynamics and cytoskeletal organization. TPPP proteins, particularly TPPP/p25 and TPPP3. are highly expressed in oligodendrocytes and ciliated cells, playing roles in myelination, cell differentiation, and ciliary function. TPPP/p25 is notable for its association with α-synuclein in pathological aggregates found in neurodegenerative disorders like multiple system atrophy (MSA) and Parkinson’s disease, suggesting its involvement in disease mechanisms.

Antibodies against TPPP are critical tools in neuroscience research, enabling the detection of TPPP expression patterns, protein interactions, and pathological inclusions. They are widely used in techniques such as immunohistochemistry, Western blotting, and immunofluorescence to study TPPP's physiological roles and its dysregulation in diseases. In diagnostic contexts, TPPP antibodies help identify MSA-specific pathological features, differentiating them from other synucleinopathies. Additionally, emerging studies explore TPPP's potential as a biomarker or therapeutic target, given its dual role in cytoskeletal integrity and disease-associated aggregation. Research continues to clarify TPPP isoforms' distinct functions and their implications in both neurological disorders and cancer biology.