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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02119(TCTE3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The TCTE3 (T-complex-associated-testis-expressed 3) antibody is a tool used to study the TCTE3 protein, a component of the outer dynein arm (ODA) complex in cilia and flagella. TCTE3 is part of the dynein motor machinery critical for the movement of motile cilia and sperm flagella. It plays a role in male fertility, as mutations in TCTE3 or related dynein components are linked to primary ciliary dyskinesia (PCD) and asthenozoospermia (reduced sperm motility).

Antibodies targeting TCTE3 are primarily utilized in research to investigate ciliary/flagellar structure, sperm motility mechanisms, and genetic disorders affecting ciliary function. They enable protein localization via immunofluorescence, Western blotting, or immunohistochemistry, helping to assess TCTE3 expression levels or structural abnormalities in clinical or experimental models. Commercially available TCTE3 antibodies are typically raised in rabbits or mice, often validated for specificity using knockout controls.

Recent studies also explore TCTE3's potential roles beyond reproduction, including respiratory cilia function and embryonic development. However, challenges remain in standardizing antibody performance across species or sample types due to sequence conservation and tissue-specific isoforms. Researchers emphasize the need for rigorous validation to avoid cross-reactivity with other dynein-associated proteins.