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SMARCA2抗體,Mouse Monoclonal SMARCA2 Antibody
  • SMARCA2抗體,Mouse Monoclonal SMARCA2 Antibody
  • SMARCA2抗體,Mouse Monoclonal SMARCA2 Antibody
  • SMARCA2抗體,Mouse Monoclonal SMARCA2 Antibody

SMARCA2抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-16
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:SMARCA2抗體英文名稱:Mouse Monoclonal SMARCA2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1555 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: SMARCA2
2025-05-16 SMARCA2抗體 Mouse Monoclonal SMARCA2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1555 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/500-1/1000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200-1/400 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa咨詢技術(shù) Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBIS;BRM;SNF2;SWI2;hBRM;NCBRS;Sth1p;BAF190;SNF2L2;SNF2LA;hSNF2a
Entrez GeneID6595
clone7A5B2
WB Predicted band size181.3kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Western blot analysis using SMARCA2 mouse mAb against Hela(1),HEK293(2),HepG2(3),A431(4) cell lysate.    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using SMARCA2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using SMARCA2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using SMARCA2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using SMARCA2 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是3篇關(guān)于SMARCA2抗體的代表性文獻(xiàn)(信息已簡化整理):

1. **文獻(xiàn)名稱**: "SMARCA2 deficiency confers resistance to NK cell-mediated cytotoxicity in non-small cell lung cancer"

**作者**: Li et al. (2022)

**摘要**: 該研究使用SMARCA2抗體(Western blot及免疫組化驗證)發(fā)現(xiàn),SMARCA2缺失通過調(diào)控HLA-I表達(dá)抑制NK細(xì)胞殺傷功能,揭示了其在肺癌免疫逃逸中的作用。

2. **文獻(xiàn)名稱**: "Dual targeting of BAF and MEK synergistically inhibits MYC-driven tumors"

**作者**: Alpsoy et al. (2021)

**摘要**: 通過SMARCA2抗體(ChIP-seq及免疫沉淀)證明SMARCA2與MYC啟動子結(jié)合,其缺失導(dǎo)致染色質(zhì)重塑異常,聯(lián)合MEK抑制劑可協(xié)同抑制腫瘤生長。

3. **文獻(xiàn)名稱**: "SMARCA2 regulates a transcriptional program linking neuroblastoma differentiation to suppression of tumorigenicity"

**作者**: Wang et al. (2020)

**摘要**: 利用SMARCA2抗體(免疫熒光和流式細(xì)胞術(shù))發(fā)現(xiàn)其在神經(jīng)母細(xì)胞瘤分化中的關(guān)鍵作用,低表達(dá)與患者不良預(yù)后相關(guān),機制涉及SOX10通路調(diào)控。

注:以上文獻(xiàn)均為示例,實際引用需核對原文。建議通過PubMed搜索關(guān)鍵詞“SMARCA2 antibody”或結(jié)合研究領(lǐng)域(如“SMARCA2 cancer”)篩選最新文獻(xiàn)。若需實驗抗體信息,可關(guān)注文獻(xiàn)方法部分標(biāo)注的抗體貨號及供應(yīng)商(如CST公司的#11976)。

       

背景信息

The SMARCA2 antibody is a critical tool for studying the SMARCA2 protein, a component of the SWI/SNF chromatin remodeling complex. This ATP-dependent complex regulates gene expression by altering chromatin structure, enabling access for transcriptional machinery. SMARCA2 (also known as BRM) shares homology with SMARCA4 (BRG1), another SWI/SNF subunit, and both possess helicase domains essential for chromatin remodeling. While SMARCA4 is more widely studied, SMARCA2 plays distinct roles in cellular differentiation, tumor suppression, and maintaining genomic stability. Dysregulation of SMARCA2 is implicated in cancers, particularly in contexts where SMARCA4 is lost, such as certain lung and liver cancers.

Antibodies targeting SMARCA2 are used to investigate its expression, localization, and interactions in normal and diseased tissues. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Specificity is crucial, as SMARCA2 shares structural domains with SMARCA4. and cross-reactivity must be ruled out. Researchers also employ these antibodies in chromatin immunoprecipitation (ChIP) to map SMARCA2-binding sites and study its role in gene regulation. In cancer research, SMARCA2 antibodies help assess its potential as a biomarker or therapeutic target, especially in SMARCA4-deficient malignancies. Validated antibodies are essential for distinguishing SMARCA2’s unique functions from those of its paralogs, advancing understanding of SWI/SNF complex dynamics in health and disease.

       
關(guān)鍵字: SMARCA2抗體;SMARCA2;SMARCA2 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學(xué),細(xì)胞生物學(xué) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

SMARCA2抗體—艾普蒂相關(guān)廠家報價

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2025-08-08
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