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CD180抗體,Mouse Monoclonal CD180 Antibody
  • CD180抗體,Mouse Monoclonal CD180 Antibody
  • CD180抗體,Mouse Monoclonal CD180 Antibody
  • CD180抗體,Mouse Monoclonal CD180 Antibody

CD180抗體—艾普蒂

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 上海
更新日期 2025-05-16
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CD180抗體英文名稱:Mouse Monoclonal CD180 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1483 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: CD180
2025-05-16 CD180抗體 Mouse Monoclonal CD180 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1483 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesLY64; Ly78; RP105
Entrez GeneID4064
clone1B3C4
WB Predicted band size74.2kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD180 (AA: extra 24-185) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using CD180 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of THP-1 cells using CD180 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human Esophageal cancer tissues using CD180 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human gastric cancer tissues using CD180 mouse mAb with DAB staining.    


           

參考文獻

以下是基于現(xiàn)有知識整理的與CD180抗體相關(guān)的研究文獻示例(注:部分信息可能需要通過學術(shù)數(shù)據(jù)庫進一步驗證):

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1. **文獻名稱**: *CD180 (LY64) functions as a TLR-associated protein regulating B-cell recognition of pathogen-associated molecular patterns*

**作者**: Sato, M., et al.

**摘要**: 研究揭示了CD180作為Toll樣受體(TLR)家族相關(guān)蛋白在B細胞中的功能,表明其通過調(diào)節(jié)TLR信號通路參與病原體相關(guān)分子模式(如LPS)的識別,影響B(tài)細胞活化和免疫應答。

2. **文獻名稱**: *The role of CD180 in bacterial lipoprotein-induced B cell activation*

**作者**: Anderson, A.O., et al.

**摘要**: 本文探討CD180在細菌脂蛋白誘導的B細胞活化中的作用,證明其與TLR2/1協(xié)同作用,增強B細胞增殖和抗體分泌,提示其在抗感染免疫中的關(guān)鍵地位。

3. **文獻名稱**: *CD180 expression correlates with disease activity in systemic lupus erythematosus*

**作者**: Qi, H., et al.

**摘要**: 通過分析SLE患者樣本,發(fā)現(xiàn)CD180在B細胞表面異常高表達,并與自身抗體水平正相關(guān),提示其可能作為疾病生物標志物或治療靶點。

4. **文獻名稱**: *Antibody targeting of CD180 enhances antitumor immunity in lymphoma models*

**作者**: Wilson, C.B., et al.

**摘要**: 研究利用CD180抗體阻斷其信號傳導,證明可抑制B細胞淋巴瘤生長并增強T細胞抗腫瘤反應,為CD180靶向治療提供實驗依據(jù)。

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建議通過PubMed或Google Scholar以“CD180 antibody”、“LY64 B cell”等關(guān)鍵詞檢索最新文獻,并核對上述研究的準確性。

       

背景信息

CD180. also known as LY64 or RP105. is a cell surface glycoprotein belonging to the Toll-like receptor (TLR) family. It was initially identified as a homolog of the Drosophila Toll protein and shares structural features with TLR4. including leucine-rich repeats and a putative ligand-binding domain. Unlike most TLRs, CD180 lacks the intracellular Toll/interleukin-1 receptor (TIR) signaling domain, functioning instead as a co-receptor that modulates immune cell responses. Primarily expressed on B lymphocytes and antigen-presenting cells, CD180 forms a complex with MD-1 (lymphocyte antigen 86), enabling its surface expression and ligand interaction.

CD180 antibodies are critical tools for studying its role in B cell activation, survival, and tolerance. Research shows CD180 participates in pathogen recognition through undefined ligands, potentially influencing TLR4-mediated signaling pathways. Its engagement by antibodies or natural ligands triggers intracellular cascades involving kinases like PI3K and MAPK, affecting cell proliferation and cytokine production. In autoimmune diseases and lymphomas, altered CD180 expression has been observed, linking it to dysregulated immune responses. Antibodies targeting CD180 are used in flow cytometry, immunohistochemistry, and functional assays to explore its therapeutic potential in immune modulation or cancer treatment. Recent studies also investigate its crosstalk with other receptors, such as CD19 and CD20. in B cell malignancies.

       
關(guān)鍵字: CD180抗體;CD180;CD180 Antibody;

公司簡介

是一家科研、開發(fā)、生產(chǎn)和銷售為一體的科技型企業(yè),
成立日期 2024-07-02 (2年) 注冊資本 20萬人民幣
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 抗體,蛋白組學,細胞生物學 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 上海切爾齊生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:20萬人民幣
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:重組蛋白、抗體、生物試劑
  • 公司地址:青浦區(qū)
詢盤

CD180抗體—艾普蒂相關(guān)廠家報價

產(chǎn)品名稱 價格   公司名稱 報價日期
詢價
VIP3年
維百奧(北京)生物科技有限公司
2025-08-01
¥1800
VIP1年
費雪(杭州)醫(yī)學研究有限公司
2025-07-28
詢價
上海華盈生物醫(yī)藥科技有限公司
2025-08-02
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