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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Western blot analysis using IL1RAPL1 mouse mAb against A431 (1), SK-Hep-1 (2), and HL-7702 (3) cell lysate.    

  
  

The interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is a protein encoded by the *IL1RAPL1* gene located on the X chromosome. It belongs to the IL-1 receptor/Toll-like receptor superfamily and plays a critical role in neurodevelopment, particularly in synapse formation and neuronal connectivity. IL1RAPL1 mutations are associated with X-linked intellectual disability (XLID), autism spectrum disorders (ASD), and neuropsychiatric conditions. The protein interacts with presynaptic partners like PTPδ to regulate excitatory synapse development and modulates intracellular signaling pathways involved in dendritic spine maturation.

Antibodies targeting IL1RAPL1 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They enable researchers to detect IL1RAPL1 in brain tissues, cell lines, or experimental models using techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies also aid in elucidating molecular mechanisms underlying synaptic defects in neurodevelopmental disorders. Commercially available IL1RAPL1 antibodies are typically validated for specificity, often targeting epitopes in the extracellular or cytoplasmic domains. Their applications extend to biomarker research and therapeutic exploration, as dysregulated IL1RAPL1 pathways are potential targets for treating cognitive impairments.