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AKR1B10抗體,Rabbit Polyclonal AKR1B10 Antibody
  • AKR1B10抗體,Rabbit Polyclonal AKR1B10 Antibody
  • AKR1B10抗體,Rabbit Polyclonal AKR1B10 Antibody
  • AKR1B10抗體,Rabbit Polyclonal AKR1B10 Antibody

AKR1B10抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:AKR1B10抗體英文名稱:Rabbit Polyclonal AKR1B10 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3767 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): AKR1B10
2025-05-13 AKR1B10抗體 Rabbit Polyclonal AKR1B10 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3767 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesHIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12
WB Predicted band size36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human AKR1B10
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: P07806(AKR1B10 Antibody) at dilution 1/184, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P07806(AKR1B10 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07806(AKR1B10 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻(xiàn)

1. **"AKR1B10 as a biomarker for hepatocellular carcinoma" by Yan et al.**

該研究通過免疫組化分析,證實(shí)AKR1B10在肝癌組織中高表達(dá),提出其作為肝癌早期診斷及預(yù)后的潛在生物標(biāo)志物。

2. **"AKR1B10 overexpression in colorectal cancer and chemoresistance" by Li et al.**

利用Western blot和免疫熒光技術(shù),發(fā)現(xiàn)AKR1B10在結(jié)腸癌中顯著上調(diào),并與5-氟尿嘧啶耐藥性相關(guān),提示其作為治療靶點(diǎn)的可能性。

3. **"AKR1B10 in lung adenocarcinoma: Diagnostic implications" by Wang et al.**

通過組織芯片和免疫組化檢測,發(fā)現(xiàn)AKR1B10在肺腺癌中特異性高表達(dá),可作為區(qū)分腺癌與其他肺部病變的輔助診斷指標(biāo)。

4. **"AKR1B10 expression correlates with breast cancer progression" by Chen et al.**

研究采用免疫組化及生存分析,揭示AKR1B10在乳腺癌中的高表達(dá)與腫瘤轉(zhuǎn)移、復(fù)發(fā)及患者不良預(yù)后顯著相關(guān)。

       

背景信息

The AKR1B10 (aldo-keto reductase family 1 member B10) antibody is a key tool for studying the role of AKR1B10. an enzyme implicated in cancer metabolism and chemoresistance. AKR1B10 belongs to the aldo-keto reductase superfamily, which catalyzes the reduction of carbonyl compounds, including toxic aldehydes and ketones, into their corresponding alcohols. Initially identified as a liver-specific protein, AKR1B10 is overexpressed in several cancers, such as hepatocellular carcinoma, lung adenocarcinoma, and breast cancer, where it promotes cell proliferation, detoxification of chemotherapeutic agents (e.g., daunorubicin), and lipid metabolism regulation. Its upregulation is associated with poor prognosis and resistance to therapies.

Antibodies targeting AKR1B10 are widely used in research to detect its expression and localization in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate AKR1B10's functional roles, such as its interaction with retinoid metabolism pathways or involvement in oxidative stress responses. Monoclonal antibodies against AKR1B10 are particularly valuable for specificity in distinguishing it from homologous enzymes like AKR1B1. Additionally, AKR1B10 antibodies hold potential diagnostic value, as elevated protein levels in serum or tissues may serve as biomarkers for early cancer detection or therapeutic monitoring. Ongoing studies explore their utility in targeted therapies to inhibit AKR1B10's oncogenic activity.

       
關(guān)鍵字: AKR1B10抗體;AKR1B10;AKR1B10 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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AKR1B10抗體相關(guān)廠家報(bào)價(jià)

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2025-08-20
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VIP3年
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