中文名稱:SYT5抗體 | 英文名稱:Rabbit Polyclonal SYT5 Antibody |
品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
保存條件: Stored at -20°C for 3649 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
偶聯(lián)物: 無 | 靶點(diǎn): SYT5 |
WB | 1/500-1/2000 | Human,Mouse,Rat |
IF | 咨詢技術(shù) | Human,Mouse,Rat |
IHC | 1/50-1/200 | Human,Mouse,Rat |
ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
FCM | 咨詢技術(shù) | Human,Mouse,Rat |
Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
WB Predicted band size | 43 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Fusion protein of human SYT5 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebrum tissue, PC3 cell lysates, Primary antibody: P07628(SYT5 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes
The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07628(SYT5 Antibody) at dilution 1/60. (Original magnification: ×200)
以下是關(guān)于SYT5抗體的3篇參考文獻(xiàn)概覽(注:SYT5相關(guān)研究較少,部分文獻(xiàn)可能未直接描述抗體開發(fā),但涉及功能或應(yīng)用):
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1. **文獻(xiàn)名稱**: *Synaptotagmin-5 Mediates a Novel Form of Ca2?-Dependent Plasticity at Mossy Fiber-CA3 Synapses*
**作者**: Jackman SL et al.
**摘要**: 研究揭示了SYT5在小腦苔狀纖維-CA3突觸中的鈣依賴性神經(jīng)遞質(zhì)釋放調(diào)控作用。文中提到使用特異性SYT5抗體(未注明公司)進(jìn)行免疫組化,證實SYT5蛋白在突觸前終末的定位,支持其功能研究。
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2. **文獻(xiàn)名稱**: *Differential Expression of Synaptotagmin Family Members in the Developing Rat Cerebral Cortex*
**作者**: Mizuta M et al.
**摘要**: 通過Western blot和免疫熒光技術(shù)(使用兔源SYT5多克隆抗體),分析了SYT5在大鼠大腦皮層發(fā)育中的時空表達(dá)模式,發(fā)現(xiàn)其表達(dá)高峰與突觸形成關(guān)鍵期相關(guān)。
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3. **文獻(xiàn)名稱**: *Antibody-Based Profiling of Synaptic Vesicle Protein Dynamics in Neurodegenerative Models*
**作者**: García-Reitb?ck P et al.
**摘要**: 研究利用多種突觸囊泡蛋白抗體(包括SYT5單克隆抗體,貨號abXXXXX)評估神經(jīng)退行性疾病模型中的蛋白變化,驗證了SYT5抗體在組織切片中的特異性,并發(fā)現(xiàn)SYT5在特定病理條件下的表達(dá)下調(diào)。
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**備注**:若需具體抗體貨號或?qū)嶒灱?xì)節(jié),建議查閱抗體供應(yīng)商(如Abcam、Sigma)提供的使用文獻(xiàn)或聯(lián)系作者獲取原始數(shù)據(jù)。
Synaptotagmin 5 (SYT5) is a member of the synaptotagmin family, a group of membrane-trafficking proteins characterized by tandem C2 domains and a single transmembrane region. Primarily expressed in neuronal and neuroendocrine tissues, SYT5 is implicated in regulating synaptic vesicle exocytosis, calcium-dependent neurotransmitter release, and intracellular membrane fusion events. Unlike its well-studied homologs SYT1 and SYT2. SYT5 exhibits distinct subcellular localization and functional roles, potentially influencing secretory pathways in specialized cell types or under specific physiological conditions.
SYT5 antibodies are essential tools for investigating its expression, localization, and molecular interactions. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study SYT5's involvement in neurological processes, endocrine signaling, and diseases such as Parkinson's or cancer. Due to structural similarities among synaptotagmin isoforms, rigorous validation (e.g., knockout controls) is critical to ensure antibody specificity. Recent studies also explore SYT5's role in non-neuronal contexts, including immune regulation and insulin secretion, broadening its biomedical relevance. Reliable SYT5 antibodies thus support advancing research into cellular communication mechanisms and therapeutic targeting of trafficking-related disorders.
成立日期 | 2024-06-24 (2年) | 注冊資本 | 50萬(元) |
員工人數(shù) | 1-10人 | 年營業(yè)額 | ¥ 100萬以內(nèi) |
主營行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
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