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ROCK2抗體,Rabbit Polyclonal ROCK2 Antibody
  • ROCK2抗體,Rabbit Polyclonal ROCK2 Antibody
  • ROCK2抗體,Rabbit Polyclonal ROCK2 Antibody
  • ROCK2抗體,Rabbit Polyclonal ROCK2 Antibody

ROCK2抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:ROCK2抗體英文名稱:Rabbit Polyclonal ROCK2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3622 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): ROCK2
2025-05-13 ROCK2抗體 Rabbit Polyclonal ROCK2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3622 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500-1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesROCK-II
WB Predicted band size161 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human ROCK2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P07582(ROCK2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07582(ROCK2 Antibody) at dilution 1/130. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于ROCK2抗體的3篇示例參考文獻(xiàn)(注:文獻(xiàn)信息為模擬示例,僅供參考):

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1. **文獻(xiàn)名稱**:*"ROCK2-Specific Antibody Reveals Its Role in Cancer Cell Invasion via Cytoskeletal Remodeling"*

**作者**:Li, X. et al.

**摘要**:本研究利用ROCK2特異性抗體,通過(guò)免疫印跡和免疫熒光技術(shù),揭示了ROCK2在乳腺癌細(xì)胞中通過(guò)調(diào)節(jié)肌動(dòng)蛋白骨架促進(jìn)侵襲轉(zhuǎn)移的機(jī)制,并證明其與患者預(yù)后不良相關(guān)。

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2. **文獻(xiàn)名稱**:*"Targeting ROCK2 with a Monoclonal Antibody Attenuates Neuroinflammation in Alzheimer's Disease Models"*

**作者**:Smith, J. & Patel, R.

**摘要**:文章報(bào)道了一種新型抗ROCK2單克隆抗體的開發(fā),并在阿爾茨海默病小鼠模型中驗(yàn)證其效果。結(jié)果顯示,該抗體通過(guò)抑制ROCK2活性減少tau蛋白過(guò)度磷酸化及神經(jīng)炎癥反應(yīng)。

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3. **文獻(xiàn)名稱**:*"ROCK2 Inhibition by a Neutralizing Antibody Improves Cardiac Fibrosis in Hypertensive Rats"*

**作者**:Yamamoto, K. et al.

**摘要**:研究使用ROCK2中和抗體干預(yù)高血壓模型大鼠,發(fā)現(xiàn)其能顯著降低心肌纖維化標(biāo)志物(如膠原沉積),提示ROCK2抗體在心血管疾病治療中的潛在應(yīng)用價(jià)值。

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如需真實(shí)文獻(xiàn),建議通過(guò)PubMed或Google Scholar搜索關(guān)鍵詞(如“ROCK2 antibody”、“ROCK2 inhibitor”),并篩選近年高影響力期刊的研究(如*Nature Cell Biology*、*Journal of Biological Chemistry*等)。

       

背景信息

The Rho-associated coiled-coil kinase 2 (ROCK2) antibody is a crucial tool for studying the ROCK2 protein, a serine/threonine kinase belonging to the AGC family of kinases. ROCK2. along with its isoform ROCK1. plays a pivotal role in regulating cytoskeletal dynamics, cell adhesion, migration, and apoptosis through its interaction with Rho GTPases, particularly RhoA. It mediates downstream signaling by phosphorylating substrates such as myosin light chain (MLC) and LIM kinase, influencing actomyosin contractility and stress fiber formation.

ROCK2 is implicated in diverse physiological and pathological processes, including cardiovascular remodeling, neuronal degeneration, cancer metastasis, and fibrosis. Its overexpression or hyperactivity has been linked to hypertension, atherosclerosis, and glaucoma. The ROCK2 antibody enables detection and quantification of ROCK2 expression in tissues and cell lines via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It also aids in elucidating ROCK2's spatial-temporal localization and activation status under experimental or disease conditions.

Researchers frequently use ROCK2-specific antibodies to validate gene silencing (e.g., siRNA/CRISPR) or assess pharmacological inhibition by compounds like fasudil or Y-27632. As ROCK2-selective inhibitors gain traction in drug development, high-specificity antibodies are essential for distinguishing ROCK2 from ROCK1. which share ~65% homology but exhibit distinct tissue distributions and functions. This underscores the antibody's importance in both basic research and therapeutic targeting of ROCK2-associated pathways.

       
關(guān)鍵字: ROCK2抗體;ROCK2;ROCK2 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
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  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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