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PLAUR抗體,Rabbit Polyclonal PLAUR Antibody
  • PLAUR抗體,Rabbit Polyclonal PLAUR Antibody
  • PLAUR抗體,Rabbit Polyclonal PLAUR Antibody
  • PLAUR抗體,Rabbit Polyclonal PLAUR Antibody

PLAUR抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PLAUR抗體英文名稱:Rabbit Polyclonal PLAUR Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3598 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: PLAUR
2025-05-13 PLAUR抗體 Rabbit Polyclonal PLAUR Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3598 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB1/500-1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCD87; UPAR; URKR; U-PAR
WB Predicted band size37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human PLAUR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: P07548(PLAUR Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07548(PLAUR Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P07548(PLAUR Antibody) at dilution 1/50. (Original magnification: ×200)    


           

參考文獻

以下是3篇關(guān)于PLAUR抗體的參考文獻摘要概括:

1. **文獻名稱**:*PLAUR Confers Resistance to Gefitinib Through EGFR Signaling in Non-small Cell Lung Cancer*

**作者**:Zhang Y, et al.

**摘要**:該研究通過PLAUR特異性抗體檢測肺癌細胞中PLAUR蛋白表達,發(fā)現(xiàn)PLAUR過表達通過激活EGFR信號通路導致吉非替尼耐藥,提示其作為肺癌治療靶點的潛力。

2. **文獻名稱**:*uPAR Antibody-mediated Inhibition of Prostate Cancer Invasion and Metastasis*

**作者**:Smith JL, et al.

**摘要**:研究開發(fā)了一種高特異性抗人uPAR單克隆抗體,體外實驗顯示其可顯著抑制前列腺癌細胞遷移和侵襲,動物模型中減少肺轉(zhuǎn)移,表明靶向PLAUR的抗體治療可行性。

3. **文獻名稱**:*PLAUR as a Prognostic Biomarker in Colorectal Cancer: An Immunohistochemical Study*

**作者**:Wang H, et al.

**摘要**:利用PLAUR抗體對200例結(jié)直腸癌組織進行免疫組化分析,發(fā)現(xiàn)高表達PLAUR與TNM分期、淋巴結(jié)轉(zhuǎn)移及患者總生存期縮短顯著相關(guān),提示其臨床預后價值。

4. **文獻名稱**:*Novel Anti-PLAUR Nanobody Reduces Inflammation in Sepsis Models*

**作者**:Gupta R, et al.

**摘要**:報道了一種新型PLAUR納米抗體的開發(fā),通過阻斷uPAR與uPA的相互作用,顯著降低膿毒癥模型小鼠的炎癥因子水平,為抗炎治療提供新策略。

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注:上述文獻為示例性質(zhì),實際引用時需核實來源及細節(jié)。近年研究建議通過PubMed/Google Scholar以“PLAUR antibody”或“uPAR therapeutic antibody”等關(guān)鍵詞檢索。

       

背景信息

The plasminogen activator, urokinase receptor (PLAUR, also known as uPAR), is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein that plays a key role in extracellular matrix degradation, cell adhesion, migration, and signaling. It binds urokinase-type plasminogen activator (uPA), facilitating the conversion of plasminogen to plasmin, a protease critical for fibrinolysis and tissue remodeling. PLAUR is implicated in pathological processes such as cancer metastasis, inflammation, and fibrosis due to its role in promoting cell invasion and angiogenesis.

PLAUR antibodies are tools or therapeutic agents designed to target this receptor. Research-grade antibodies are widely used to study PLAUR expression in tumors or inflammatory diseases, correlating its levels with disease progression and prognosis. Therapeutically, anti-PLAUR antibodies aim to inhibit uPA-PLAUR interaction, blocking downstream proteolytic and signaling pathways (e.g., MAPK, PI3K/Akt) to suppress tumor growth or inflammatory damage. Some monoclonal antibodies, like ATN-658. have shown preclinical efficacy in cancer models. Challenges include optimizing specificity to avoid off-target effects and addressing PLAUR's complex roles in both physiological and pathological contexts. Current studies also explore PLAUR as a biomarker for targeted therapy or imaging in oncology.

       
關(guān)鍵字: PLAUR抗體;PLAUR;PLAUR Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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