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NEUROG3抗體,Rabbit Polyclonal NEUROG3 Antibody
  • NEUROG3抗體,Rabbit Polyclonal NEUROG3 Antibody
  • NEUROG3抗體,Rabbit Polyclonal NEUROG3 Antibody
  • NEUROG3抗體,Rabbit Polyclonal NEUROG3 Antibody

NEUROG3抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-13
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:NEUROG3抗體英文名稱:Rabbit Polyclonal NEUROG3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3564 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: NEUROG3
2025-05-13 NEUROG3抗體 Rabbit Polyclonal NEUROG3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3564 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/1000-1/5000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

Aliasesngn3; Atoh5; NGN-3; Math4B; bHLHa7
WB Predicted band size23 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human heart tissue lysate, Primary antibody: P07483(NEUROG3 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 second    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07483(NEUROG3 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

參考文獻

1. **"Neurogenin3 is required for the development of the human endocrine pancreas"**

- **作者**: McGrath, P.S., et al.

- **摘要**: 研究使用特異性NEUROG3抗體,證實其在人類胚胎胰腺內(nèi)分泌前體細胞中的表達,揭示其驅(qū)動胰島細胞分化的關(guān)鍵作用,為糖尿病機制提供依據(jù)。

2. **"Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the β-cell differentiation"**

- **作者**: Schwitzgebel, V.M., et al.

- **摘要**: 通過NEUROG3抗體標(biāo)記小鼠胰腺祖細胞,發(fā)現(xiàn)其活性窗口期決定β細胞分化效率,強調(diào)時間調(diào)控對胰島發(fā)育的重要性。

3. **"Neurogenin3 delineates the earliest stages of enteroendocrine cell differentiation in the gut epithelium"**

- **作者**: Jenny, M., et al.

- **摘要**: 利用NEUROG3抗體追蹤腸道上皮細胞,揭示其在腸內(nèi)分泌細胞早期分化中的標(biāo)志性表達,為腸道激素分泌細胞研究提供工具。

4. **"Antibody validation and neurogenin3 function in pancreatic islet development"**

- **作者**: Gradwohl, G., et al.

- **摘要**: 驗證多種NEUROG3抗體的特異性,結(jié)合基因敲除模型證明其在胰島形成中的必要性,為抗體應(yīng)用提供可靠性數(shù)據(jù)。

(注:以上文獻信息為示例性質(zhì),實際文獻需通過學(xué)術(shù)數(shù)據(jù)庫檢索確認。)

       

背景信息

NEUROG3 (Neurogenin 3) is a basic helix-loop-helix (bHLH) transcription factor critical for endocrine cell differentiation during development. It serves as a master regulator in the formation of pancreatic islet cells and intestinal enteroendocrine cells. NEUROG3 antibodies are essential tools for detecting and studying the expression, localization, and function of this protein in developmental biology, diabetes research, and gastrointestinal studies. These antibodies are typically generated against specific epitopes of human or murine NEUROG3. often targeting its C-terminal or N-terminal regions.

Validated in assays like immunohistochemistry (IHC), Western blot, and immunofluorescence (IF), NEUROG3 antibodies help identify progenitor cells committing to endocrine lineages. Researchers use them to investigate NEUROG3's role in diseases such as neonatal diabetes, maturity-onset diabetes of the young (MODY), and neuroendocrine tumors, where its expression or mutations may disrupt normal cell differentiation. Commercial NEUROG3 antibodies are available as monoclonal or polyclonal formats, often verified in knockout models to ensure specificity.

Studies leveraging these antibodies have clarified mechanisms of β-cell regeneration and intestinal hormone production, offering insights into therapeutic strategies for diabetes and gut disorders. Proper validation, including species reactivity and cross-reactivity checks, remains crucial due to NEUROG3's transient expression and low abundance in tissues.

       
關(guān)鍵字: NEUROG3抗體;NEUROG3;NEUROG3 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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