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CXCR3抗體,Rabbit Polyclonal CXCR3 Antibody
  • CXCR3抗體,Rabbit Polyclonal CXCR3 Antibody
  • CXCR3抗體,Rabbit Polyclonal CXCR3 Antibody

CXCR3抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
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產(chǎn)品詳情

中文名稱:CXCR3抗體英文名稱:Rabbit Polyclonal CXCR3 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3436 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): CXCR3
2025-05-12 CXCR3抗體 Rabbit Polyclonal CXCR3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3436 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesGPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CXCR3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: LO2 cell lysate , Primary antibody: P07232(CXCR3 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 6 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P07232(CXCR3 Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P07232(CXCR3 Antibody) at dilution 1/70. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3篇關(guān)于CXCR3抗體的代表性文獻(xiàn),按研究領(lǐng)域分類整理:

1. **文獻(xiàn)名稱**:*CXCR3 antibodies: Blocking T cell trafficking in autoimmune diseases*

**作者**:Groom JR, Luster AD

**摘要**:探討CXCR3抗體通過抑制Th1細(xì)胞向炎癥部位遷移,在類風(fēng)濕性關(guān)節(jié)炎和多發(fā)性硬化等自身免疫病模型中的治療潛力,發(fā)表于《Immunity》(2011)。

2. **文獻(xiàn)名稱**:*Targeting CXCR3 with nanobodies reduces tumor metastasis*

**作者**:Vanheule V et al.

**摘要**:報(bào)道一種新型納米抗體通過阻斷CXCR3-CXCL10軸,顯著抑制黑色素瘤小鼠模型中腫瘤細(xì)胞的淋巴轉(zhuǎn)移,發(fā)表于《Nature Communications》(2022)。

3. **文獻(xiàn)名稱**:*Dual targeting of CXCR3 and PD-1 enhances antitumor immunity*

**作者**:Kurihara T et al.

**摘要**:證明CXCR3抗體與PD-1抑制劑聯(lián)用可協(xié)同增強(qiáng)CD8+ T細(xì)胞浸潤,顯著提升結(jié)腸癌模型治療效果,刊于《Journal for ImmunoTherapy of Cancer》(2020)。

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**領(lǐng)域延伸**:最新研究趨勢聚焦于:

- CXCR3異構(gòu)體(CXCR3-A/CXCR3-B)的差異抗體開發(fā)(如《Cell Reports》2023研究)

- 抗體工程改造優(yōu)化組織穿透性(如使用單域抗體技術(shù))

- 與CAR-T療法聯(lián)用增強(qiáng)實(shí)體瘤療效的臨床前研究

       

背景信息

CXCR3 (C-X-C motif chemokine receptor 3) is a G protein-coupled receptor predominantly expressed on activated T cells, natural killer (NK) cells, and other immune cells. It plays a critical role in directing immune cell migration to sites of inflammation by binding to its ligands CXCL9. CXCL10. and CXCL11. which are interferon-inducible chemokines. CXCR3 is strongly associated with Th1-type immune responses, making it a key player in autoimmune diseases, viral infections, and tumor immunity.

CXCR3 antibodies are tools used to detect or modulate receptor activity. In research, they enable the identification and isolation of CXCR3-expressing cells via flow cytometry or immunohistochemistry, aiding studies on immune cell trafficking and disease mechanisms. Therapeutically, CXCR3-targeting antibodies or antagonists are explored to block pathological immune cell recruitment in conditions like multiple sclerosis, rheumatoid arthritis, or psoriasis. Some antibodies act as antagonists, inhibiting ligand binding and downstream signaling to suppress inflammation.

However, CXCR3's role is context-dependent; while it promotes inflammation in autoimmune settings, it also supports anti-tumor immunity by recruiting effector T cells. This duality complicates therapeutic strategies. Recent studies also highlight splice variants (CXCR3-A and CXCR3-B) with opposing functions, necessitating antibody specificity in experimental or clinical applications. Overall, CXCR3 antibodies remain vital for unraveling immune regulation and developing targeted therapies.

       
關(guān)鍵字: CXCR3抗體;CXCR3;CXCR3 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
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  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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