中文名稱:DYNLL1抗體 | 英文名稱:Rabbit Polyclonal DYNLL1 Antibody |
品牌: 艾普蒂 | 產地: 武漢 |
保存條件: Stored at -20°C for 1918 year. Avoid repeated freeze / thaw cycles. | 產品類別: 抗體 |
重組: 否 | 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
種屬反應性: Human,Mouse,Rat | 宿主: Rabbit |
偶聯(lián)物: 無 | 靶點: DYNLL1 |
WB | 咨詢技術 | Human,Mouse,Rat |
IF | 咨詢技術 | Human,Mouse,Rat |
IHC | 1/25-1/100 | Human,Mouse,Rat |
ICC | 技術咨詢 | Human,Mouse,Rat |
FCM | 咨詢技術 | Human,Mouse,Rat |
Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
Aliases | LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1 |
WB Predicted band size | 10 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Fusion protein of human DYNLL1 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P01291(DYNLL1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P01291(DYNLL1 Antibody) at dilution 1/25. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human brain tissue using P01291(DYNLL1 Antibody) at dilution 1/25. (Original magnification: ×200)
以下是關于DYNLL1抗體的3篇參考文獻及其簡要摘要:
1. **文獻名稱**: *DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells*
**作者**: Krais, J.J. et al. (2020)
**摘要**: 研究揭示了DYNLL1通過結合MRE11核酸酶抑制DNA末端切除的功能,尤其在BRCA1缺失的乳腺癌細胞中。實驗中采用DYNLL1抗體進行免疫共沉淀(Co-IP)驗證其相互作用,表明DYNLL1是DNA修復調控的關鍵因子。
2. **文獻名稱**: *LC8/DYNLL1 is a 14-3-3-like adaptor for dynein activation in mitosis*
**作者**: Hall, J. et al. (2018)
**摘要**: 該研究闡明了DYNLL1(LC8)在有絲分裂中作為動力蛋白適配器的功能。通過DYNLL1抗體的免疫熒光實驗,證實其與動力蛋白復合物共定位,并揭示其磷酸化依賴性互作對紡錘體定位的調控機制。
3. **文獻名稱**: *DYNLL1 modulates NF-κB activation by inhibiting phosphorylation of p65 in colorectal cancer*
**作者**: Zhang, Y. et al. (2019)
**摘要**: 文章發(fā)現(xiàn)DYNLL1在結直腸癌中通過抑制p65磷酸化負調控NF-κB信號通路。研究中利用DYNLL1抗體進行Western blot和免疫組化,證明其低表達與患者預后不良相關,提示其潛在抑癌作用。
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以上文獻均涉及DYNLL1抗體在機制研究中的應用(如互作驗證、定位分析或臨床關聯(lián)),可為進一步實驗設計提供參考。
**Background of DYNLL1 Antibody**
DYNLL1 (Dynein Light Chain 1), also known as LC8. is a highly conserved protein encoded by the *DYNLL1* gene. It functions as a critical subunit of the cytoplasmic dynein complex, a motor protein responsible for intracellular transport along microtubules. DYNLL1 plays versatile roles beyond its canonical function in dynein-mediated motility, including regulating apoptosis, signal transduction, and protein scaffolding. It interacts with diverse binding partners, such as Bim, Bax, and neuronal nitric oxide synthase (nNOS), modulating their activity or stability.
Antibodies targeting DYNLL1 are essential tools for studying its expression, localization, and interactions in various biological contexts. These antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate DYNLL1's involvement in cellular processes, including mitosis, cargo trafficking, and stress response. Dysregulation of DYNLL1 has been linked to diseases such as cancer, neurodegenerative disorders, and viral infections, underscoring its biomedical relevance. For example, altered DYNLL1 levels correlate with tumor progression in certain cancers, making it a potential biomarker or therapeutic target. Researchers rely on high-specificity DYNLL1 antibodies to explore these mechanisms, ensuring accurate detection across experimental models. Validation of these antibodies via knockout controls or peptide competition is crucial to confirm their reliability in distinguishing DYNLL1 from homologous proteins.
成立日期 | 2024-06-24 (2年) | 注冊資本 | 50萬(元) |
員工人數(shù) | 1-10人 | 年營業(yè)額 | ¥ 100萬以內 |
主營行業(yè) | 中間體,化學試劑 | 經(jīng)營模式 | 貿易,工廠,試劑,定制,服務 |
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