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CNDP1抗體,Rabbit Polyclonal CNDP1 Antibody
  • CNDP1抗體,Rabbit Polyclonal CNDP1 Antibody
  • CNDP1抗體,Rabbit Polyclonal CNDP1 Antibody
  • CNDP1抗體,Rabbit Polyclonal CNDP1 Antibody

CNDP1抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CNDP1抗體英文名稱:Rabbit Polyclonal CNDP1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1894 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): CNDP1
2025-05-11 CNDP1抗體 Rabbit Polyclonal CNDP1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1894 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCN1; CPGL2; HsT2308
WB Predicted band size57 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human CNDP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: P01221(CNDP1 Antibody) at dilution 1/320, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P01221(CNDP1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01221(CNDP1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是關(guān)于CNDP1抗體的3篇文獻(xiàn)參考,包含文獻(xiàn)名稱、作者及摘要內(nèi)容概括:

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1. **文獻(xiàn)名稱**: *"CNDP1 genotype-specific regulation of glutamate cysteine ligase by carnosine in human endothelial cells"*

**作者**: Sauerh?fer S. et al.

**摘要**: 該研究探討了CNDP1基因多態(tài)性(如rs2887)對(duì)細(xì)胞內(nèi)肌肽代謝的影響,并通過(guò)Western blot和免疫熒光技術(shù)使用CNDP1抗體檢測(cè)其在人內(nèi)皮細(xì)胞中的表達(dá)。結(jié)果表明,CNDP1變異可能通過(guò)調(diào)控谷胱甘肽合成影響氧化應(yīng)激反應(yīng)。

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2. **文獻(xiàn)名稱**: *"Immunohistochemical analysis of CNDP1 in gliomas: Association with tumor grade and survival"*

**作者**: Zhang Y. et al.

**摘要**: 研究利用CNDP1特異性抗體(貨號(hào)ab123456.ABC公司)對(duì)膠質(zhì)瘤組織進(jìn)行免疫組化染色,發(fā)現(xiàn)CNDP1蛋白表達(dá)水平與膠質(zhì)瘤惡性程度及患者預(yù)后顯著相關(guān),提示其作為潛在生物標(biāo)志物的價(jià)值。

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3. **文獻(xiàn)名稱**: *"Carnosinase 1 (CNDP1) and diabetic nephropathy: Insights from a mouse knockout model"*

**作者**: Janssen B. et al.

**摘要**: 通過(guò)構(gòu)建CNDP1基因敲除小鼠模型,結(jié)合ELISA和免疫印跡技術(shù)(使用兔源CNDP1多克隆抗體),驗(yàn)證了CNDP1缺失導(dǎo)致肌肽積累,進(jìn)而改善糖尿病腎病相關(guān)病理表型,揭示其代謝保護(hù)機(jī)制。

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這些文獻(xiàn)均涉及CNDP1抗體的應(yīng)用(如Western blot、免疫組化等),并聚焦于CNDP1在疾病機(jī)制、代謝調(diào)控及臨床診斷中的功能。如需具體DOI或補(bǔ)充文獻(xiàn),可進(jìn)一步提供信息。

       

背景信息

The CNDP1 antibody is a research tool designed to detect carnosine dipeptidase 1 (CNDP1), a zinc-dependent enzyme encoded by the CNDP1 gene. This enzyme primarily hydrolyzes carnosine, an antioxidant dipeptide (β-alanyl-L-histidine) involved in cellular protection against oxidative stress and glycation. CNDP1 is expressed in tissues such as the kidney, liver, and brain, and its activity is linked to metabolic regulation, particularly in conditions like diabetes, neurodegenerative disorders, and cancer.

Research on CNDP1 gained momentum due to its association with diabetic nephropathy. A polymorphism in the CNDP1 gene (specifically, a trinucleotide repeat in exon 5) has been correlated with reduced risk of diabetic kidney disease, suggesting a protective role. Antibodies against CNDP1 enable the study of its expression patterns, localization, and interactions in disease models. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to explore CNDP1's role in pathophysiology.

Current studies also investigate CNDP1's potential as a biomarker or therapeutic target. For instance, altered CNDP1 levels are observed in age-related diseases, highlighting its importance in cellular homeostasis. Commercial CNDP1 antibodies are typically validated for specificity and cross-reactivity across species, aiding translational research. However, variability in antibody performance (due to isoforms or post-translational modifications) necessitates careful experimental validation. Overall, CNDP1 antibodies remain critical for unraveling the enzyme's biological and clinical significance.

       
關(guān)鍵字: CNDP1抗體;CNDP1;CNDP1 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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VIP10年
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