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OCLN抗體,Rabbit Polyclonal OCLN Antibody
  • OCLN抗體,Rabbit Polyclonal OCLN Antibody
  • OCLN抗體,Rabbit Polyclonal OCLN Antibody
  • OCLN抗體,Rabbit Polyclonal OCLN Antibody

OCLN抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:OCLN抗體英文名稱:Rabbit Polyclonal OCLN Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1731 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): OCLN
2025-05-11 OCLN抗體 Rabbit Polyclonal OCLN Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1731 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBLCPMG; PTORCH1; PPP1R115
WB Predicted band size59 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human OCLN
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue lysate, Primary antibody: P00583(OCLN Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P00583(OCLN Antibody) at dilution 1/70. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3篇與OCLN抗體相關(guān)的研究文獻(xiàn)概覽:

1. **"Occludin: a novel integral membrane protein localizing at tight junctions"**

*作者:Furuse M, Hirase T, Itoh M, et al.*

摘要:該研究首次發(fā)現(xiàn)并命名了Occludin(OCLN),利用特異性抗體證實(shí)其定位在細(xì)胞緊密連接處,揭示了其在維持上皮屏障功能中的關(guān)鍵作用。

2. **"Antibody-based profiling of cerebrovascular endothelial cells for claudin-5 and occludin in Alzheimer's disease"**

*作者:Branyan TE, Sridharan S, Shah S, et al.*

摘要:通過(guò)OCLN抗體和Claudin-5抗體的免疫熒光分析,發(fā)現(xiàn)阿爾茨海默病模型中腦血管內(nèi)皮細(xì)胞緊密連接蛋白表達(dá)異常,提示血腦屏障破壞機(jī)制。

3. **"Development and validation of monoclonal antibodies specific for human occludin isoforms"**

*作者:Runkle EA, Mu D.*

摘要:研究團(tuán)隊(duì)開(kāi)發(fā)了針對(duì)人類OCLN不同亞型的單克隆抗體,驗(yàn)證了其特異性在Western blot和免疫組化中的應(yīng)用,為亞型功能研究提供工具。

注:以上內(nèi)容為基于領(lǐng)域知識(shí)的模擬文獻(xiàn)概括,實(shí)際文獻(xiàn)請(qǐng)通過(guò)PubMed或Google Scholar以關(guān)鍵詞“occludin antibody”檢索獲取最新研究。

       

背景信息

Occludin (OCLN) is a key transmembrane protein component of tight junctions (TJs), specialized cell-cell adhesion structures critical for maintaining epithelial and endothelial barrier integrity. First identified in 1993. OCLN spans the plasma membrane four times, with both N- and C-termini located intracellularly. It interacts with cytoplasmic scaffolding proteins like ZO-1 to anchor TJs to the actin cytoskeleton. While its exact functional mechanisms remain debated, OCLN contributes to paracellular barrier formation, cell polarity, and signal transduction.

OCLN antibodies are essential tools for studying TJ dynamics in physiological and pathological contexts. They enable detection of OCLN expression/localization through techniques like immunofluorescence, Western blotting, and immunohistochemistry. Researchers use these antibodies to investigate barrier dysfunction in diseases such as inflammatory bowel disease, cancer metastasis (via epithelial-mesenchymal transition), and neurological disorders involving blood-brain barrier leakage. Species-specific and isoform-targeting antibodies (e.g., recognizing phosphorylated forms) help dissect post-translational regulation of OCLN during processes like hypoxia or immune cell transmigration.

Notably, OCLN knockout models show viable but leaky epithelial barriers, suggesting compensatory mechanisms by other TJ proteins like claudins. This underscores the importance of antibody validation using appropriate controls (e.g., knockout tissues) to ensure specificity. Commercial OCLN antibodies often differ in epitope recognition, requiring careful selection based on experimental needs.

       
關(guān)鍵字: OCLN抗體;OCLN;OCLN Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤(pán)

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OCLN抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1280
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