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mouse Lplunc1抗體,Mouse Monoclonal mouseLplunc1 Antibody
  • mouse Lplunc1抗體,Mouse Monoclonal mouseLplunc1 Antibody
  • mouse Lplunc1抗體,Mouse Monoclonal mouseLplunc1 Antibody
  • mouse Lplunc1抗體,Mouse Monoclonal mouseLplunc1 Antibody

mouse Lplunc1抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:mouse Lplunc1抗體英文名稱:Mouse Monoclonal mouseLplunc1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 511 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: mouse Lplunc1
2025-05-10 mouse Lplunc1抗體 Mouse Monoclonal mouseLplunc1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 511 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBpifb1; RP23-154J12.1
Entrez GeneID228801
clone4H2
WB Predicted band size52.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of mouse Lplunc1 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of HeLa cells using Lplunc1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of MCF-7 cells using Lplunc1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using Lplunc1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human muscle tissues using Lplunc1 mouse mAb with DAB staining.    


           

參考文獻

以下是3-4條關(guān)于小鼠Lplunc1抗體的參考文獻摘要(文獻標(biāo)題、作者及內(nèi)容概述基于模擬生成,可能需要進一步驗證):

1. **"A monoclonal antibody against mouse Lplunc1 identifies its expression in nasal epithelium and role in innate immunity"**

- **作者**: Zhang Y, et al.

- **摘要**: 本研究開發(fā)了一種針對小鼠Lplunc1蛋白的單克隆抗體,通過免疫組化和Western blot驗證了其在鼻腔上皮細(xì)胞中的高表達。研究發(fā)現(xiàn)Lplunc1可能通過抑制病原體黏附參與先天免疫防御。

2. **"Lplunc1 modulates airway inflammation in a murine model of allergic asthma"**

- **作者**: Li X, et al.

- **摘要**: 利用抗小鼠Lplunc1抗體,研究者發(fā)現(xiàn)該蛋白在哮喘模型中表達下調(diào),并通過調(diào)節(jié)TLR4信號通路減輕氣道炎癥和黏液分泌,提示其作為潛在治療靶點。

3. **"Characterization of Lplunc1-deficient mice reveals its protective role against respiratory pathogens"**

- **作者**: Wang H, et al.

- **摘要**: 通過Lplunc1抗體檢測基因敲除小鼠的蛋白表達缺失,證實Lplunc1缺失導(dǎo)致肺部對肺炎鏈球菌易感性增加,表明其在宿主防御中的關(guān)鍵作用。

4. **"Tissue-specific distribution of Lplunc1 in murine mucosal surfaces and its interaction with surfactant proteins"**

- **作者**: Kumar S, et al.

- **摘要**: 使用抗Lplunc1抗體進行組織定位分析,發(fā)現(xiàn)該蛋白在小鼠口腔、鼻腔及肺部分布廣泛,并與表面活性蛋白相互作用,可能在維持黏膜屏障功能中發(fā)揮作用。

**提示**:以上文獻為示例性質(zhì),實際引用時建議通過PubMed或Google Scholar以關(guān)鍵詞“mouse Lplunc1 antibody”或“murine Lplunc1”檢索最新文章,并核對實驗細(xì)節(jié)是否匹配您的研究方向。

       

背景信息

The mouse Lplunc1 (Palate, Lung, and Nasal Epithelium Clone 1) antibody is a tool used to detect and study the Lplunc1 protein, a member of the Bactericidal/Permeability-Increasing (BPI) protein family. Lplunc1. also known as BPIFA1 or SPLUNC1. is primarily expressed in mucosal surfaces, including the oral cavity, respiratory tract, and upper aerodigestive tract. It plays a role in innate immunity, contributing to host defense against pathogens through mechanisms such as binding to bacterial lipopolysaccharides (LPS), modulating inflammation, and maintaining epithelial barrier integrity.

The antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant Lplunc1 protein. It is utilized in applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate Lplunc1's expression patterns, localization, and regulation in tissues. Studies using this antibody have highlighted Lplunc1's involvement in chronic inflammatory conditions (e.g., cystic fibrosis, chronic rhinosinusitis), airway infections, and cancers, where its expression is often dysregulated. Researchers also employ it to explore Lplunc1's structural domains—an N-terminal hydrophobic region for lipid interaction and a C-terminal globular domain for immune signaling. Its role in mucosal immunity and potential as a biomarker or therapeutic target underscores the antibody's relevance in both basic and translational research.

       
關(guān)鍵字: mouse Lplunc1抗體;mouse Lplunc1;mouse Lplunc1 Antibo;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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