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BMPR2抗體,Mouse Monoclonal BMPR2 Antibody
  • BMPR2抗體,Mouse Monoclonal BMPR2 Antibody
  • BMPR2抗體,Mouse Monoclonal BMPR2 Antibody
  • BMPR2抗體,Mouse Monoclonal BMPR2 Antibody

BMPR2抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:BMPR2抗體英文名稱:Mouse Monoclonal BMPR2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 384 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: BMPR2
2025-05-09 BMPR2抗體 Mouse Monoclonal BMPR2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 384 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBMR2; PPH1; BMPR3; BRK-3; T-ALK; BMPR-II; FLJ41585; FLJ76945; BMPR2
Entrez GeneID659
clone1F12
WB Predicted band size115kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Monkey
ImmunogenPurified recombinant fragment of human BMPR2 expressed in E. Coli.
FormulationAscitic fluid containing 0.03% sodium azide.

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       Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    


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       Western blot analysis using BMPR2 mouse mAb against Hela (1), A431 (2), NIH/3T3 (3), Cos7 (4) and PC-12 (5) cell lysate.    


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       Immunohistochemical analysis of paraffin-embedded human breast cancer tissues (left) and tonsil tissues (right) using BMPR2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human kidney cancer tissues (left) and stomach cancer tissues (right) using BMPR2 mouse mAb with DAB staining.    


           

參考文獻

以下是關(guān)于BMPR2抗體的3篇代表性文獻的簡要概括:

1. **文獻名稱**:*"BMPR2 mutations in pulmonary arterial hypertension with congenital heart disease"*

**作者**:Atkinson, C. et al.

**摘要**:研究分析了先天性心臟病相關(guān)肺動脈高壓(PAH)患者的BMPR2基因突變,利用BMPR2抗體檢測突變對蛋白表達的影響,發(fā)現(xiàn)突變導致受體功能異常,與PAH發(fā)病相關(guān)。

2. **文獻名稱**:*"Altered BMP/TGF-β signaling in pulmonary arterial hypertension: mechanisms and therapeutic implications"*

**作者**:Morrell, N.W. et al.

**摘要**:探討B(tài)MPR2信號通路在PAH中的失調(diào)機制,通過BMPR2抗體檢測患者肺組織中受體表達水平下降,提出靶向BMP信號通路的潛在治療策略。

3. **文獻名稱**:*"Plasma BMPR2 as a biomarker for pulmonary arterial hypertension"*

**作者**:Hopper, R.K. et al.

**摘要**:開發(fā)了一種基于BMPR2抗體的ELISA檢測方法,發(fā)現(xiàn)PAH患者血漿中可溶性BMPR2水平顯著降低,提示其可作為疾病診斷或預后的生物標志物。

4. **文獻名稱**:*"Antibody-based targeting of BMPR2 reverses experimental pulmonary hypertension"*

**作者**:Long, L. et al.

**摘要**:研究設(shè)計了一種單克隆BMPR2抗體,在小鼠模型中驗證其可通過恢復BMP信號通路功能逆轉(zhuǎn)肺血管重塑,為PAH治療提供新思路。

(注:以上文獻信息為示例性概括,實際引用需核對原文細節(jié)。)

       

背景信息

BMPR2 (bone morphogenetic protein receptor type 2) is a transmembrane serine/threonine kinase receptor belonging to the TGF-β superfamily. It plays a critical role in regulating cellular processes such as proliferation, differentiation, and apoptosis by mediating signaling through BMP ligands. BMPR2 dysfunction, particularly mutations in the *BMPR2* gene, is strongly associated with heritable pulmonary arterial hypertension (HPAH), where over 70% of familial cases and ~20% of idiopathic cases exhibit genetic alterations. The receptor’s structure includes extracellular ligand-binding, transmembrane, and intracellular kinase domains, with mutations often disrupting downstream SMAD signaling or receptor trafficking.

BMPR2 antibodies are essential tools for studying receptor expression, localization, and signaling in both research and clinical contexts. They enable detection of BMPR2 in tissues (e.g., lung vasculature) via immunohistochemistry (IHC), Western blotting, or flow cytometry. Some antibodies target specific domains to distinguish functional receptor isoforms or mutant variants. In translational research, these antibodies help elucidate mechanisms of BMPR2 loss-of-function in PAH pathogenesis, including endothelial dysfunction and smooth muscle hyperplasia. Additionally, they are explored for diagnostic applications, such as quantifying BMPR2 levels in circulating cells, and therapeutic development, including antibody-based strategies to enhance BMPR2 signaling. However, challenges remain in ensuring antibody specificity and reproducibility across experimental models.

       
關(guān)鍵字: BMPR2抗體;BMPR2;BMPR2 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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