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PFN2抗體,Rabbit Polyclonal PFN2 Antibody
  • PFN2抗體,Rabbit Polyclonal PFN2 Antibody
  • PFN2抗體,Rabbit Polyclonal PFN2 Antibody
  • PFN2抗體,Rabbit Polyclonal PFN2 Antibody

Rabbit Polyclonal PFN2 Antibody

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-09
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:PFN2抗體英文名稱:Rabbit Polyclonal PFN2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 101 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 無(wú)靶點(diǎn): PFN2
2025-05-09 PFN2抗體 Rabbit Polyclonal PFN2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 101 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesIPOB; IPO-B; MNSOD; MVCD6; Mn-SOD
Entrez GeneID6648
clone8H3D2
WB Predicted band size24.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human SOD2 (AA: 1-222) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using SOD2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using SOD2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using SOD2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using SOD2 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于PFN2抗體的3篇代表性文獻(xiàn)的簡(jiǎn)要概括(注:文獻(xiàn)信息為模擬示例,實(shí)際引用需核實(shí)):

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1. **文獻(xiàn)名稱**: *Profilin-2 (PFN2) promotes tumor progression via epithelial-mesenchymal transition in colorectal cancer*

**作者**: Li Y, et al. (2020)

**摘要**: 該研究通過(guò)PFN2抗體檢測(cè)發(fā)現(xiàn),PFN2在結(jié)直腸癌組織中高表達(dá),并通過(guò)調(diào)控EMT通路促進(jìn)腫瘤轉(zhuǎn)移。實(shí)驗(yàn)表明PFN2抗體可用于Western blot和免疫組化分析腫瘤樣本中的蛋白定位。

2. **文獻(xiàn)名稱**: *PFN2 modulates synaptic plasticity by regulating actin dynamics in Alzheimer's disease models*

**作者**: Smith J, et al. (2019)

**摘要**: 利用PFN2特異性抗體,研究揭示了PFN2在阿爾茨海默病模型中對(duì)突觸可塑性的影響,發(fā)現(xiàn)PFN2通過(guò)肌動(dòng)蛋白重組參與神經(jīng)元功能退化,抗體應(yīng)用于腦組織免疫熒光染色。

3. **文獻(xiàn)名稱**: *Profilin-2 as a novel biomarker for pancreatic cancer: Validation using a commercial PFN2 antibody*

**作者**: Wang H, et al. (2021)

**摘要**: 研究驗(yàn)證了一種商業(yè)化PFN2抗體的靈敏度與特異性,發(fā)現(xiàn)PFN2在胰腺癌患者血清中顯著升高,提示其作為診斷標(biāo)志物的潛力,抗體應(yīng)用于ELISA和流式細(xì)胞術(shù)檢測(cè)。

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**說(shuō)明**:以上文獻(xiàn)為模擬示例,實(shí)際研究中需通過(guò)學(xué)術(shù)數(shù)據(jù)庫(kù)(如PubMed、Web of Science)檢索具體文獻(xiàn),并確認(rèn)抗體貨號(hào)及實(shí)驗(yàn)細(xì)節(jié)。PFN2抗體常用于研究其在細(xì)胞骨架調(diào)控、癌癥轉(zhuǎn)移及神經(jīng)系統(tǒng)疾病中的作用。

       

背景信息

The profilin-2 (PFN2) antibody is a crucial tool in studying the role of profilin-2. a member of the profilin family of actin-binding proteins. Profilins regulate cytoskeletal dynamics by interacting with actin monomers and phosphoinositides, influencing cell motility, membrane trafficking, and signal transduction. Unlike the ubiquitously expressed profilin-1 (PFN1), PFN2 is predominantly found in the nervous system, particularly in neurons, where it modulates synaptic plasticity and neurotransmitter release. Its involvement in neurological disorders, such as Parkinson’s and Alzheimer’s disease, has driven research interest.

PFN2 antibodies are widely used to investigate protein expression, localization, and function in cellular and tissue contexts. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the characterization of PFN2’s role in neuronal development, synaptic function, and disease mechanisms. Studies have linked PFN2 dysregulation to aberrant actin polymerization, synaptic dysfunction, and neurodegenerative pathology.

Recent advances highlight PFN2’s interaction with pathogenic proteins (e.g., α-synuclein) and its potential as a biomarker or therapeutic target. However, antibody specificity remains critical, as PFN1/PFN2 structural similarities may lead to cross-reactivity. Validated PFN2 antibodies thus provide essential insights into neurobiology and disease pathways, bridging molecular mechanisms with clinical implications. Ongoing research continues to unravel its multifaceted roles in health and disease.

       
關(guān)鍵字: PFN2抗體;PFN2;PFN2 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
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  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP3年
武漢佰樂(lè)博生物技術(shù)有限公司
2025-07-25
¥960.00
VIP10年
北京索萊寶科技有限公司
2025-07-25
¥1950
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-07-25
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