TYRO3產品信息
英文名稱:TYRO3 protein tyrosine kinase
中文名稱:TYRO3蛋白酪氨酸激酶
靶點別稱:TYRO3,BYK,DTK,RSE,SKY,TIF
物種:Human
標簽:Fc Tag
屬性:Protein
標記:Unconjugated
表達區(qū)間及表達系統(tǒng)(Source)
Human TYRO3, Fc Tag (TY3-H5251) is expressed from human 293 cells (HEK293). It contains AA Ala 41 - Ser 428 (Accession # AAH51756.1 (Q261H)).
Predicted N-terminus: Ala 41
蛋白結構(Molecular Characterization)

This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 68.2 kDa. The protein migrates as 86-106 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.

背景(Background)
酪氨酸蛋白激酶受體TYRO3也稱為酪氨酸蛋白激酶BYK、DTK、RSE、SKY、TIF,屬于蛋白激酶超家族、Tyr蛋白激酶家族和AXL/UFO亞家族。TYRO3調節(jié)許多生理過程,包括細胞存活、遷移和分化。TYRO3激活AKT存活途徑,包括NF-kappa-B的核轉位和NF-kappa-B調節(jié)基因轉錄的上調。TYRO3(通過N端)與細胞外配體TULP1和GAS6相互作用。通過相似性以及與PIK3R1的相互作用,這種相互作用增加了PI3激酶活性。
關鍵字: TYRO3;TYRO3蛋白;TYRO3重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下擁有品牌ACROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。