PE-Labeled Monoclonal Anti-Human CD28 Antibody, Mouse IgG1 (0.03% Proclin)

抗體來源（Source）

Monoclonal Anti-Human CD28 Antibody, Mouse IgG1 is a monoclonal antibody recombinantly expressed from human 293 cells (HEK293), which provides higher batch consistency and long term security of supply.

應(yīng)用（Application）

Flow Cytometry (Evaluation of the expression of CD28 on Human cells).

種屬（Species）

Mouse

亞型（Isotype）

Mouse IgG1 | Mouse Kappa

特異性（Specificity）

This product is a specific antibody specifically reacts with CD28 protein.

種屬反應(yīng)性（Reactivity）

Human

免疫原（Immunogen）

Purified Human CD28 Protein.

偶聯(lián)（Conjugate）

PE

Excitation Wavelength: 488 nm / 561 nm

Emission Wavelength: 575 nm

同型對(duì)照（Isotype Control）

The Isotype control is sold separately and you can search for Cat. No. DNP-PM1 for product information.

推薦稀釋比（Recommended Dilution）

1:50

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, 0.2% BSA, 0.03% Proclin 300, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 12 months after reconstitution.

2-8 °C for 12 months after reconstitution.

背景（Background）

T細(xì)胞特異性表面糖蛋白CD28也稱為TP44，是一種單程I型膜蛋白，含有一個(gè)Ig樣V型（免疫球蛋白樣）結(jié)構(gòu)域。是T細(xì)胞上表達(dá)的提供T細(xì)胞活化所需的共刺激信號(hào)的分子之一。CD28是CD80（B7.1）和CD86（B7.2）的受體。當(dāng)被Toll樣受體配體激活時(shí)，CD80在抗原呈遞細(xì)胞（APCs）中的表達(dá)上調(diào)?？乖蔬f細(xì)胞上的CD86表達(dá)是組成型的。CD28是唯一在幼稚T細(xì)胞上組成型表達(dá)的B7受體。