PE-Labeled Human B7-H3 / CD276 Protein, His Tag
分子別名(Synonym)
B7-H3,CD276,B7 homolog 3
表達區(qū)間及表達系統(tǒng)(Source)
PE-Labeled Human B7-H3 Protein, His Tag (B73-HP2H3) is expressed from human 293 cells (HEK293). It contains AA Leu 29 - Pro 245 (Accession # Q5ZPR3-2).
Predicted N-terminus: Leu 29
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 37.6 kDa.
偶聯(lián)(Conjugate)
PE
Excitation Wavelength: 488 nm / 561 nm
Emission Wavelength: 575 nm
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, 0.2% BSA, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution.

背景(Background)
B7同源物3(B7-H3)是免疫球蛋白超家族的成員,也被稱為CD276,它包含兩個Ig樣C2型(免疫球蛋白樣)結(jié)構(gòu)域和兩個Ig型V型(免疫蛋白樣)的結(jié)構(gòu)域。B7-H3可能參與調(diào)節(jié)T細胞介導的免疫反應。B7-H3還通過抑制自然殺傷介導的細胞裂解在腫瘤細胞中發(fā)揮保護作用,并作為檢測神經(jīng)母細胞瘤細胞的標志物。此外,B7-H3參與急性和慢性移植排斥反應的發(fā)展以及粘膜表面淋巴細胞活性的調(diào)節(jié)。它還可以在整個懷孕期間為胎盤和胎兒提供合適的免疫環(huán)境方面發(fā)揮關(guān)鍵作用。
關(guān)鍵字: B7-H3;B7-H3蛋白;B7-H3重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。