黃腐醇|T3342|TargetMol

價(jià)格	￥248	￥578	￥913
包裝	1mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2025-03-12

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產(chǎn)品詳情

中文名稱:黃腐醇	英文名稱:Xanthohumol
CAS:6754-58-1	品牌: TargetMol
產(chǎn)地: 美國	保存條件: keep away from moisture,keep away from direct sunlight,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
純度規(guī)格: 99.19%	產(chǎn)品類別: 抑制劑
貨號(hào): T3342

Product Introduction

Bioactivity

名稱	Xanthohumol
描述	Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
細(xì)胞實(shí)驗(yàn)	HL-60 cells are maintained in RPMI 1640 supplemented with 10% FBS at 37°C in a 5% CO2 atmosphere. Log-phase cells with a population doubling time of 14–16 h are used for experiments. Serial 2-fold dilutions of compounds (dissolved in DMSO, final concentration 0.1%) in a final concentration range of 0.2–12.5 μM are prepared in 24-well plates using 1 ml of RPMI/well. Control wells obtain the same amount of solvent. Subsequently, 1 ml of the cell suspension is added to the wells. After 96 h, the experiment is evaluated. Cell numbers are counted using a Casy 1 TTC flow-cytometer. The proliferation of treated cells is expressed as a percentage in comparison with the solvent control.(Only for Reference)
激酶實(shí)驗(yàn)	Inhibition of Cox Activity: Inhibition of Cox-1 activity is measured by monitoring oxygen consumption during the conversion of arachidonic acid to PGs using a Clark-type O2-electrode. The reaction mixture contains ～0.2 units Cox-1 in 100 μL of microsome fraction derived from ram seminal vesicles as a crude source of Cox-1 (specific activity 0.2–1 units/mg protein) or 0.23 units of recombinant human Cox-2 (specific activity 43 units/mg protein). For calculation, the rate of O2 consumption is compared with a DMSO control (100% activity). Piroxicam, a nonsteroidal anti-inflammatory drug, is used as positive inhibitory substance for Cox-1 activity with an IC50 of 0.35 ± 0.05 μM (n = 2). Alternatively, nimesulide, a Cox-2 specific inhibitor, inhibits Cox-2 activity by 52 ± 5.7% (n = 2) at a concentration of 50 μM.
體外活性	Xanthohumol抑制小鼠肝癌細(xì)胞培養(yǎng)中的Cyp1A活性并誘導(dǎo)QR活性。Xanthohumol清除活性氧物種，抑制超氧陰離子自由基和一氧化氮的產(chǎn)生。此外，Xanthohumol通過抑制DNA合成、誘導(dǎo)細(xì)胞周期在S期停滯、凋亡及細(xì)胞分化來阻止癌癥的發(fā)生。[1] Xanthohumol還顯示出強(qiáng)大的抗HIV-1活性。[2]
體內(nèi)活性	在CETP-Tg小鼠中，黃腐酚（p.o.）阻止膽固醇積聚導(dǎo)致動(dòng)脈粥樣硬化。[3] 在TRAMP小鼠中，黃腐酚（p.o.）促成尿生殖道（UG）平均重量下降, 延緩高級(jí)腫瘤進(jìn)展并抑制低分化前列腺癌的生長。[4]
存儲(chǔ)條件	keep away from moisture,keep away from direct sunlight,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度	Ethanol : 35.4 mg/mL (99.89 mM), Sonication is recommended. DMSO : 5.63 mg/mL (15.87 mM), Sonication is recommended.
關(guān)鍵字	Xanthohumol \| mono- acylglycerol acyltransferase \| Inhibitor \| inhibit \| InfluenzaVirus \| Influenza Virus \| HSV \| Herpes simplex virus \| Diglyceride acyltransferase \| Diacylglycerol acyltransferase \| Cytomegalovirus \| Cyclooxygenase \| COX \| CMV \| Apoptosis \| Acyltransferase \| acyl-CoA:cholesterol acyltransferase
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相關(guān)庫	抑制劑庫 \| 抗癌活性化合物庫 \| 植物來源化合物庫 \| 清熱解毒中藥單體庫 \| 苗藥化合物庫 \| 中藥單體化合物庫 \| 天然產(chǎn)物庫 \| 抗病毒庫 \| 抗病毒中藥單體化合物庫 \| 免疫/炎癥分子化合物庫 \| 抗癌臨床化合物庫 \| 抗癌藥物庫

關(guān)鍵字：黃腐醇|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （13年）	注冊(cè)資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國（陶術(shù)生物）

VIP 13年

公司成立：13年
注冊(cè)資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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