Human IL-13 Protein, His Tag, premium grade
分子別名（Synonym）
IL13,ALRH,BHR1,MGC116786,MGC116788,MGC116789,P600,Interleukin-13
表達區(qū)間及表達系統(tǒng)（Source）
Human IL-13 Protein, His Tag, premium grade (IL3-H52H4) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Asn 132 (Accession # AAK53823.1).
Predicted N-terminus: Gly 21
Human IL-13 Protein, His Tag, premium grade (IL3-H52H4), designed for preclinical stage, has the same activity and performance with GMP Human IL-13 Protein, which enables a seamless transition from preclinical development to clinical phases. Premium Grade product offer a cost efficient alternative of GMP Grade products for the early development phase when safety of raw materials is not top priority. By using Premium Grade products in early development phase, you can transition easily into clinical and commercial phase without need to revalidate the raw materials and modify manufacturing process.
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 14.2 kDa. The protein migrates as 15 kDa and 25-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 0.1 EU per μg by the LAL method.
無菌（Sterility）
Negative
支原體（Mycoplasma）
Negative.
純度（Purity）
>90% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
白細胞介素13（IL13）也稱為ALRH、BHR1和P600，是一種單鏈糖基化多肽，是調(diào)節(jié)炎癥和免疫反應的關(guān)鍵細胞因子。IL13由許多細胞類型分泌，但特別是由T輔助型2（Th2）細胞分泌。IL-13通過多亞基受體誘導其作用，該受體包括IL-4受體的α鏈（IL-4Rα）和兩個已知的IL-13特異性結(jié)合鏈中的至少一個。IL-13的功能與IL-4的功能相當重疊，特別是在造血細胞誘導的變化方面，但考慮到IL-4更有效的作用，這些作用可能不那么重要。IL-13誘導基質(zhì)金屬蛋白酶（MMPs），作為防止易窒息的過度過敏性炎癥機制的一部分。IL-13誘導過敏性肺病的許多特征，包括氣道高反應性、杯狀細胞化生和粘液分泌過多，這些都會導致氣道阻塞。
關(guān)鍵字： IL-13;IL-13蛋白;IL-13重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。