中文名：4,6-二(4-嗎啉基)-N-(4-硝基苯基)-1,3,5-三嗪-2-胺
英文名：MHY1485
英文別名：4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
純度：10mM in DMSO
貨號：M408199
包裝：1ml
Cas號：326914-06-1
存儲溫度：-80℃儲存
產(chǎn)品介紹：
Information
MHY1485 MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy .
In?vitro
MHY1485 suppresses the basal autophagic flux. MHY1485 causes the accumulation of LC3II and enlargement of the autophagosomes in a dose- and time- dependent manner. MHY1485 increases phospho-mTOR levels and phosphorylation of downstream S6K1 and rpS6 proteins without affecting total mTOR content, total S6K1 and rpS6 levels. Short-term treatment of ovaries with MHY1485 followed by allo-transplantation promoted secondary follicle growth. Treatment with MHY1485 and subsequent grafting allowed the derivation of mature oocytes and healthy offspring.
In?vivo
Cell?Data
cell?lines：
Concentrations：
Incubation?Time：
Powder?Purity:≥97%
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關(guān)鍵字： 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
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