中文名：2-(2,6-二氯苯氨基)苯乙酸

英文名：Diclofenac

中文別名：雙氯芬酸|奧爾芬

英文別名：diclofenac|Diclofenac acid|15307-86-5|dichlofenac|Diclofenacum|Diclophenac|Diclofenaco|ProSorb-D|2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid|Diclofenac resinate|Voltarol|Diclofenac free acid|2-(2,6-Dichloroanilino)phenylacetic Acid|Zorovolex|Zorvol

純度：>98.0%

貨號：D155733

包裝：25g、100g、5g

Cas號：15307-86-5

存儲溫度：2-8°C儲存

產(chǎn)品介紹：

Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. Target: COX Diclofenac is a nonsteroidal anti-inflammatory drμg (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thoμght to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

Diclofenac (雙氯芬酸) 是COX抑制劑，對綿羊的COX-1和-2的IC50分別為60和220 nM。

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