中文名稱:STK16-IN-1 | 英文名稱:STK16-IN-1 |
CAS:1223001-53-3 | 純度規(guī)格: 98% |
產(chǎn)品類別: 生物試劑 |
STK16-IN-1 is a cell-permeable pyrrolonaphthyridinone compound that acts as an ATP-competitive inhibitor against NAK (Numb Associated Kinase) family serine/threonine kinase STK16 (IC50/substrate = 0.91 μM/4EBP1 and 1.2 μM/DRG1, [ATP] = 20 μM) with excellent selectivity over a panel of 378 kinases. Despite its inhibitory potency against PI 3-Ks (IC50 = 1.07, 0.856, 0.867 μM against p110α/p85α, p110σ/p85α, p110γ , respectively) in cell-free assays, STK16-IN-1 is ineffective against their cellular activity up to 10 μM concentration. STK16-IN-1 treatment (10 μM for 72 hrs) is shown to cause cell number reduction (~50% in HCT-116 and MCF-7 cultures), as well as increased populations of binucleated cells (~5-fold in MCF-7 culture) and G2/M cells (~7 and 3-fold in HCT-116 and MCF-7 cultures, respectively) in an STK16-dependent manner. A useful tool for elucidating STK16 biological functions.
成立日期 | 2021-03-31 (5年) | 注冊資本 | 20萬人民幣 |
員工人數(shù) | 1-10人 | 年營業(yè)額 | ¥ 100萬以內(nèi) |
主營行業(yè) | 醫(yī)藥中間體,原料藥,有機合成藥,氨基酸及其衍生物 | 經(jīng)營模式 | 工廠,試劑,定制 |
產(chǎn)品名稱 | 價格 | 公司名稱 | 報價日期 | |
---|---|---|---|---|
詢價 |
VIP6年
|
上海澤葉生物科技有限公司
|
2025-08-01 | |
¥118 |
VIP4年
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TargetMol中國(陶術(shù)生物)
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2025-07-28 | |
¥1132.90 |
VIP2年
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上海阿拉丁生化科技股份有限公司
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2025-05-16 |