Rabbit Anti-CRTAM Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:CRTAM
IR:Immunogen Range:31-130/393
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:56253
Swiss Prot:O95727
Source:KLH conjugated synthetic peptide derived from human CRTAM:31-130/393
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:CRTAM, (class-I MHC-restricted T-cell associated molecule), is an immunoglobulin-superfamily transmembrane protein and a new member of the nectin-like (Necls) family. In the immune system, CRTAM expression has been shown to be restricted to activated class-I MHC-restricted T cells, including NKT and CD8 T cells. CRTAM interacts with CADM1 and promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro, as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Nectin-like (Necl) molecule 2, has been identified as a ligand of CRTAM. Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Pig
Rabbit
僅供科研使用。不能用于人和動(dòng)物治療等其它臨床診斷用！
關(guān)鍵字： CRTAM;CD355;Class I MHC restrict;Class-I MHC-restrict;CRTAM;Cytotoxic and regula;Cytotoxic and regula;CRTAM_HUMAN;
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