Name: VH 032 amide-alkylC3-acid
CAS#: 2172819-73-5
Chemical Formula: C27H36N4O6S
Exact Mass: 544.2356
Molecular Weight: 544.667
Elemental Analysis: C, 59.54; H, 6.66; N, 10.29; O, 17.62; S, 5.89
Description: VH 032 amide-alkylC3-acid is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC? research and development. It incorporates an E3 ligase ligand plus alkylC3 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. VH 032 amide-alkylC3-acid is part of a range of functionalized tool molecules for PROTAC R&D.
IUPAC/Chemical Name: 5-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentanoic acid
InChi Key: FKGREQKARAJLQH-JXALWOEJSA-N
InChi Code: InChI=1S/C27H36N4O6S/c1-16-23(38-15-29-16)18-10-8-17(9-11-18)13-28-25(36)20-12-19(32)14-31(20)26(37)24(27(2,3)4)30-21(33)6-5-7-22(34)35/h8-11,15,19-20,24,32H,5-7,12-14H2,1-4H3,(H,28,36)(H,30,33)(H,34,35)/t19-,20+,24-/m1/s1
SMILES Code: CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCC(O)=O)=O)C(C)(C)C)=O)=O)C=C2
Appearance: Solid powder
關(guān)鍵字： 2172819-73-5;amide;
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