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| Cas No.: | 5534-09-8 |
| SMILES: | CCC(OCC([C@]1([C@@H](C)CC2[C@@H]3CCC4=CC(C=C[C@]4(C)C3(Cl)[C@H](C[C@]12C)O)=O)OC(CC)=O)=O)=O |
| Formula: | C28H37ClO7 |
| M.Wt: | 521.05 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Beclometasone dipropionate is a potent glucocorticoid agonist; it is a prodrug of the free form, beclometasone.in vitro: Cortisol and beclomethasone dipropionate were more potent than salbutamol in inhibiting thymidine incorporation with IC50 values of 5 nM and 0.2 nM respectively. Cortisol 100 nM led to a 16.6 +/- 6.5% reduction and beclomethasone dipropionate 3 nM led to a 17.8 +/- 5.8% reduction in cell number. in vivo: Controlled trials involving 497 adults and children demonstrated similar clinical efficacy between nebulized BDP and either nebulized fluticasone propionate or nebulized budesonide. Meta-analyses show that BDP, like other inhaled corticosteroids, has no major influence on patient height, urinary cortisol concentration, or bone metabolism. Beclometasone dipropionate (BDP) 800 microgday(-1) suspension for nebulization and budesonide (BUD) 750 microg day(-1) given by nebulization in a twice-daily regimen, and when used in addition to the usual maintenance therapy, resulted in comparable clinical efficacy across all parameters. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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