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  1. Protein Tyrosine Kinase/RTK
  2. VEGFR
  3. Ranibizumab (anti-VEGF)

Ranibizumab (anti-VEGF)  (Synonyms: RG-6321 (anti-VEGF))

目錄號(hào): HY-P9951A 純度: ≥99.0%
COA 技術(shù)支持

Ranibizumab (RG-6321) (anti-VEGF) 是一種人源化的抗 VEGF 單克隆抗體片段,能夠識(shí)別所有 VEGF-A 亞型 (VEGF110,VEGF121,以及 VEGF165)。動(dòng)物模型中,Ranibizumab (anti-VEGF) 減緩視力喪失,并用于老年黃斑變性 (AMD) 的研究。

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CAS No. : 347396-82-1

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ¥2800
In-stock
5 mg ¥7200
In-stock
10 mg   詢(xún)價(jià)  
50 mg   詢(xún)價(jià)  

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查看 VEGFR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Ranibizumab (RG-6321) (anti-VEGF) is a humanized anti-VEGF monoclonal antibody fragment and can recognize all VEGF-A isoforms (VEGF110, VEGF121, and VEGF165)[1]. Ranibizumab (anti-VEGF) slows vision loss in vivo and is used for wet age-related macular degeneration (AMD) research[1].

IC50 & Target

VEGFA

體外研究
(In Vitro)

Ranibizumab (anti-VEGF) 是一種人源化VEGF單克隆抗體片段(IgG 抗原結(jié)合片段 (Fab-Y0317)[2])。Ranibizumab (anti-VEGF) (0.0625-0.25 mg/mL;72 小時(shí)) 導(dǎo)致大鼠視網(wǎng)膜細(xì)胞培養(yǎng)中壞死和凋亡增加[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

猴子實(shí)驗(yàn)表明,單次玻璃體腔注射 Ranibizumab (anti-VEGF) 后,即可迅速分布至視網(wǎng)膜(6-24小時(shí))。兔玻璃體腔注射 Ranibizumab (anti-VEGF) 后僅需1小時(shí)即可迅速穿透視網(wǎng)膜到達(dá)脈絡(luò)膜[1]。
一項(xiàng)比較兔玻璃體腔注射0.5毫克 Ranibizumab (anti-VEGF) 和1.25毫克貝伐單抗的藥代動(dòng)力學(xué)研究顯示,Ranibizumab (anti-VEGF) 的玻璃體半衰期為 2.88 天,短于貝伐單抗的 4.32 天[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

基因 ID

7422  [NCBI]

Accession
應(yīng)用

ELISA, FACS, Functional assay

偶聯(lián)物

Unconjugated

復(fù)溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

49.19 kDa

CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

運(yùn)輸條件

Shipping with dry ice.

儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Biological Activity
  • Immobilized VEGFA-FC can bind Ranibizumab (anti-VEGF). The EC50 for this effect is 10.14 ng/mL.
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻(xiàn)
  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng):
Ranibizumab (anti-VEGF)
目錄號(hào):
HY-P9951A
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